1,420 results found
    1. Medicine

    Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome

    Simone Bersini et al.
    Direct reprogramming of smooth muscle cells from HGPS patients revealed that BMP4 is a key contributor of vascular degeneration and might represent a new therapeutic target.
    1. Developmental Biology

    Endothelial TGF-β signaling instructs smooth muscle cell development in the cardiac outflow tract

    Giulia LM Boezio et al.
    Alk5/TGF-β signaling is required in the endothelium to orchestrate zebrafish cardiac outflow tract morphogenesis, regulating smooth muscle cell and extracellular matrix organization.
    1. Chromosomes and Gene Expression

    Identification of RBPMS as a mammalian smooth muscle master splicing regulator via proximity of its gene with super-enhancers

    Erick E Nakagaki-Silva et al.
    By focusing on RNA-binding proteins whose genes have super enhancers in smooth muscle cells, the protein RBPMS was identified as an alternative splicing master regulator.
    1. Developmental Biology

    A tissue-specific, Gata6-driven transcriptional program instructs remodeling of the mature arterial tree

    Marta Losa et al.
    The transcription factor GATA6 selects the embryonic vessels that will be reorganized into the major thoracic arteries by promoting local differentiation of vascular smooth muscle cells.
    1. Neuroscience
    2. Physics of Living Systems

    Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure

    Simon Bulley et al.
    Arterial myocyte PKD2 channels are activated by vasoconstrictor stimuli, which increases blood pressure, are upregulated during hypertension and cell-specific knockout in vivo reduces both physiological blood pressure and hypertension.
    1. Computational and Systems Biology
    2. Developmental Biology

    Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth

    Sumeda Nandadasa et al.
    Morphologic, molecular, biomechanical and computational analyses show that the specialized extracellular matrix architecture of the umbilical artery contributes to its rapid closure at birth and regulates smooth muscle cell differentiation.
    1. Developmental Biology
    2. Evolutionary Biology

    The evolutionary origin of bilaterian smooth and striated myocytes

    Thibaut Brunet et al.
    Molecular profiling of annelid myocytes reveals that the last common protostome-deuterostome ancestor already possessed a dual musculature, with visceral smooth muscles ensuring digestion and somatic striated muscles ensuring locomotion.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Ca2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon

    Salah A Baker et al.
    An optogenetic dual-color Ca2+-imaging approach shows how submucosal pacemaker-cells, interstitial cells of Cajal, modulate smooth-muscle responses and drive colonic motility via complex Ca2+ signaling.
    1. Developmental Biology

    Pericytes are progenitors for coronary artery smooth muscle

    Katharina S Volz et al.
    Progenitor cells for the muscle layer around the coronary arteries have been identified revealing a key step in how the embryo forms these important blood vessels.
    1. Cell Biology
    2. Developmental Biology

    Angiopoietin-4-dependent venous maturation and fluid drainage in the peripheral retina

    Harri Elamaa et al.
    Identification of importance of Angiopoietin-4 (Angpt4) as a first growth factor that initiates venous specification in the peripheral retina, and Angpt4-dependent mechanism for fluid clearance in the mouse retina.

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