The high resolution crystal structure and electrophysiology of a sodium channel complex with cannabidiol, a drug approved for treatment of severe epilepsies, demonstrate the basis for its structural- functional effects.

Allosteric gating in a transient receptor potential channel is modulated by external sodium ions and a tarantula toxin.

Not all members of the bacteria sodium channel family are sodium channels - those found in Bacillus are highly adaptable and can be converted into many selectivity types.

The sodium leak NALCN channel functions as a core effector of GABA-B and D2 receptors that is used along with GIRK channels to regulate action potential firing in dopamine neurons.

A-type fibroblast growth factor homologous factors generate resurgent currents in tetrodotoxin-resistant voltage-gated sodium channels, increase repetitive firing of sensory neurons, and provide a potentially important target for pain treatment strategies.

Kinetic interactions between sodium channels and auxiliary factors create a molecular computational engine that can sense and regulate cellular excitability.

Simulations reveal where phosphoinositide lipids bind to voltage-gated sodium channels and how they reduce channel activity.

The first structure of the human epithelial sodium channel provides vital insight into the assembly, stoichiometry and molecular mechanism of the ion channel central to sodium homeostasis.

Force applied to the cell membrane reversibly changes a voltage-insensitive gating step of a prokaryotic voltage-gated sodium channel.

A cationic molecule derived from an uncharged Cav2.2 calcium channel inhibitor powerfully inhibits both sodium and calcium channels with extracellular application and inhibits both pain and neurogenic inflammation.