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    1. Ecology

    Point of View: A transatlantic perspective on 20 emerging issues in biological engineering

    Bonnie C Wintle, Christian R Boehm ... William J Sutherland
    Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.
    1. Plant Biology

    Accurate and versatile 3D segmentation of plant tissues at cellular resolution

    Adrian Wolny, Lorenzo Cerrone ... Anna Kreshuk
    Convolutional neural networks and graph partitioning algorithms can be combined into an easy-to-use tool for segmentation of cells in dense plant tissue volumes imaged with light microscopy.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Science Forum: A survey of research quality in core facilities

    Isabelle C Kos-Braun, Björn Gerlach, Claudia Pitzer
    Responses to a survey reveal how core facilities could improve and encourage good research practices.
    1. Structural Biology and Molecular Biophysics

    Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2

    Dari Kimanius, Björn O Forsberg ... Erik Lindahl
    Using GPUs for the costly computations in cryo-EM enables structure determination in mere days on a single workstation.
    1. Epidemiology and Global Health
    2. Medicine

    External validation of a mobile clinical decision support system for diarrhea etiology prediction in children: A multicenter study in Bangladesh and Mali

    Stephanie Chow Garbern, Eric J Nelson ... Daniel T Leung
    A smartphone app incorporating clinical prediction models using patient-specific and location-specific data sources in a modular approach could predict viral-only etiology of diarrhea in children under five in Bangladesh and Mali.
    1. Developmental Biology

    ZAF, the first open source fully automated feeder for aquatic facilities

    Merlin Lange, AhmetCan Solak ... Loïc Alain Royer
    ZAF (Zebrafish Automated Feeder) is the first fully automated, easy to build, and open source fish feeder designed for small and medium sized labs of which there are an estimated 3250 in 100 countries working with Zebrafish alone today.
    1. Computational and Systems Biology

    The MR-Base platform supports systematic causal inference across the human phenome

    Gibran Hemani, Jie Zheng ... Philip C Haycock
    Compiling public datasets into a single, centralised repository and linking directly to analytical software completely transforms the scale and scope of causal inference across the phenome.
    1. Computational and Systems Biology
    2. Neuroscience

    NetPyNE, a tool for data-driven multiscale modeling of brain circuits

    Salvador Dura-Bernal, Benjamin A Suter ... William W Lytton
    The NetPyNE software tool provides a framework to efficiently develop, simulate, optimize and analyze experimentally grounded neural models spanning the molecular, cellular and circuit scales.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Multi-omics insights into host-viral response and pathogenesis in Crimean-Congo hemorrhagic fever viruses for novel therapeutic target

    Ujjwal Neogi, Nazif Elaldi ... Ali Mirazimi
    The interplay of the host metabolic reprogramming, its negative association with antiviral biological signaling pathways and the IFN-mediated host antiviral mechanism during Crimean–Congo hemorrhagic fever orthonairovirus (CCHFV) infection could provide attractive options for therapeutic intervention of CCHF.
    1. Computational and Systems Biology
    2. Neuroscience

    The natverse, a versatile toolbox for combining and analysing neuroanatomical data

    Alexander Shakeel Bates, James D Manton ... Gregory SXE Jefferis
    Open source software enables neuroscientists to integrate single neuron or synaptic-resolution datasets from different imaging modalities to analyse morphology and connectivity at the scale of whole brains and connectomes.