42 results found
    1. Structural Biology and Molecular Biophysics

    Spatial structure of disordered proteins dictates conductance and selectivity in nuclear pore complex mimics

    Adithya N Ananth et al.
    Biomimetic nanopores reveal that the sequence-dependent spatial distribution of intrinsically disordered proteins plays a crucial role in establishing the selective permeability barrier of the nuclear pore complex.
    1. Ecology
    2. Microbiology and Infectious Disease

    Freshwater monitoring by nanopore sequencing

    Lara Urban et al.
    From now on, nanopore metagenomics can be used to monitor aquatic environments with high spatiotemporal resolution, by use of a benchmarked, standardised and cost-effective workflow.
    1. Physics of Living Systems

    A physical model describing the interaction of nuclear transport receptors with FG nucleoporin domain assemblies

    Raphael Zahn et al.
    A homopolymer-sphere model is shown to accurately reproduce the interactions that underpin selective gating of macromolecular transport into and out of the cell nucleus.
    1. Cell Biology
    2. Genetics and Genomics

    Rapid re-identification of human samples using portable DNA sequencing

    Sophie Zaaijer et al.
    DNA fingerprinting by portable nanopore sequencing is a novel re-identification method with applications in (clinical) laboratories and biobanks.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Single nucleus sequencing reveals evidence of inter-nucleus recombination in arbuscular mycorrhizal fungi

    Eric CH Chen et al.
    Arbuscular mycorrhizal fungi generate nuclear diversity in the dikaryotic life-stage stage via inter-nucleus recombination.
  1. Cutting Edge: Using mobile sequencers in an academic classroom

    Sophie Zaaijer et al.
    A university genomics class provides detailed examples of how to design and execute Oxford Nanopore MinION hackathons as part of an academic curriculum.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The effect of hybridization on transposable element accumulation in an undomesticated fungal species

    Mathieu Hénault et al.
    Transposable elements are not reactivated in natural hybrids of the yeast Saccharomyces paradoxus, but their accumulation is genotype-specific and is not predicted by the evolutionary divergence between a hybrid's parents.
    1. Genetics and Genomics
    2. Neuroscience

    A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes

    François Kroll et al.
    Zebrafish knockouts can be generated in a few hours directly from wild-type eggs and are suitable for studying continuous traits, including behaviour.
    1. Genetics and Genomics

    Firefly genomes illuminate parallel origins of bioluminescence in beetles

    Timothy R Fallon et al.
    The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.
    1. Chromosomes and Gene Expression

    The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure

    Hsiang-Chen Chou et al.
    The initiation of human genome replication requires the six-subunit origin recognition complex (ORC) and CDC6, with ORC playing additional roles during mitosis and in organization of the cell nucleus.

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