441 results found
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The solubility product extends the buffering concept to heterotypic biomolecular condensates

    Aniruddha Chattaraj et al.
    The solubility product, a thermodynamic concept classically applied to poorly soluble ionic solutes, can rationalize the concentration dependence for liquid-liquid phase separation of multicomponent multivalent molecules.
    1. Structural Biology and Molecular Biophysics

    Cystic fibrosis drug ivacaftor stimulates CFTR channels at picomolar concentrations

    László Csanády, Beáta Töröcsik
    Aqueous solubility of cystic fibrosis drug ivacaftor is ~200-fold lower, whereas the potency of its stimulatory effect on the CFTR channel is >100-fold higher, than reported, and is fully reversible.
    1. Cell Biology
    2. Developmental Biology

    Dual roles for ATP in the regulation of phase separated protein aggregates in Xenopus oocyte nucleoli

    Michael H Hayes et al.
    The equilibrium between solubility and aggregation of proteins in the nucleus is controlled by co-aggregates like RNA and the action of ATP as both an energy source and a destabilizing chemical agent.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The Peptidisc, a simple method for stabilizing membrane proteins in detergent-free solution

    Michael Luke Carlson et al.
    A simple, yet elegant method for robust self-assembly of diverse membrane proteins into soluble peptide nanoparticles for their structural and functional analysis in detergent-free solutions.
    1. Biochemistry and Chemical Biology
    2. Medicine

    Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism

    Erin G Conlon et al.
    Idiopathic patients along a complex motor neuron disease-dementia spectrum exhibit mRNA splicing changes that are due to multi-protein insolubility.
    1. Biochemistry and Chemical Biology

    Skd3 (human ClpB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations

    Ryan R Cupo, James Shorter
    Skd3 (human ClpB) is a potent ATP-dependent mitochondrial protein disaggregase that is activated by the rhomboid protease, PARL, and inactivated by MGCA7-linked mutations.
    1. Cell Biology
    2. Immunology and Inflammation

    NaLi-H1: A universal synthetic library of humanized nanobodies providing highly functional antibodies and intrabodies

    Sandrine Moutel et al.
    A fully synthetic library of humanized single domain antibodies yields in vitro high affinity antibodies usable in cell biology and translational projects.
    1. Genetics and Genomics
    2. Neuroscience

    Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology

    Eric N Anderson et al.
    Traumatic injury leads to functional defects in nucleocytoplasmic transport and TDP-43 pathology in multiple model systems.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity

    Iordan Iordanov et al.
    TRPM2 is simply a ligand gated channel and does not to possess enzymatic activity, even though it shows sequence similarity to Nudix hydrolases.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin

    Emiko Mihara et al.
    Lipidated and highly hydrophobic Wnt ligands form a complex with the serum glycoprotein afamin, and can be purified and stored in a biologically active form without detergents.

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