The solubility product, a thermodynamic concept classically applied to poorly soluble ionic solutes, can rationalize the concentration dependence for liquid-liquid phase separation of multicomponent multivalent molecules.

Aqueous solubility of cystic fibrosis drug ivacaftor is ~200-fold lower, whereas the potency of its stimulatory effect on the CFTR channel is >100-fold higher, than reported, and is fully reversible.

The equilibrium between solubility and aggregation of proteins in the nucleus is controlled by co-aggregates like RNA and the action of ATP as both an energy source and a destabilizing chemical agent.

A simple, yet elegant method for robust self-assembly of diverse membrane proteins into soluble peptide nanoparticles for their structural and functional analysis in detergent-free solutions.

Idiopathic patients along a complex motor neuron disease-dementia spectrum exhibit mRNA splicing changes that are due to multi-protein insolubility.

Skd3 (human ClpB) is a potent ATP-dependent mitochondrial protein disaggregase that is activated by the rhomboid protease, PARL, and inactivated by MGCA7-linked mutations.

A fully synthetic library of humanized single domain antibodies yields in vitro high affinity antibodies usable in cell biology and translational projects.

Traumatic injury leads to functional defects in nucleocytoplasmic transport and TDP-43 pathology in multiple model systems.

TRPM2 is simply a ligand gated channel and does not to possess enzymatic activity, even though it shows sequence similarity to Nudix hydrolases.

Lipidated and highly hydrophobic Wnt ligands form a complex with the serum glycoprotein afamin, and can be purified and stored in a biologically active form without detergents.