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    1. Plant Biology

    Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis

    Katherine Noelani Chang et al.
    The plant hormone ethylene regulates the expression of multiple genes in the model plant Arabidopsis, including those that respond to other hormones.
    1. Cancer Biology
    2. Cell Biology

    Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling

    Yingqi Liu et al.
    PRMT7-mediated SHANK2 methylation regulates breast cancer metastasis by activating endosomal FAK signals, and may provide potential clues for tumour metastasis treatment strategies.
    1. Immunology and Inflammation
    2. Medicine

    Identification of specific Tie2 cleavage sites and therapeutic modulation in experimental sepsis

    Temitayo O Idowu et al.
    Matrix metalloprotease (MMP)-14 cleaves Tie2 at three distinct sites within the fibronectin type-III (FN3) domain and its pharmacological blockade inhibits Tie2 pathological shedding to exert barrier protective effects.
    1. Developmental Biology

    Nodal and planar cell polarity signaling cooperate to regulate zebrafish convergence and extension gastrulation movements

    Margot LK Williams, Lilianna Solnica-Krezel
    Nodal signaling regulates gastrulation cell behaviors largely in parallel with planar cell polarity signaling and is sufficient for ex vivo extension of embryonic explants.
    1. Developmental Biology
    2. Neuroscience

    Application of optogenetic Amyloid-β distinguishes between metabolic and physical damages in neurodegeneration

    Chu Hsien Lim et al.
    An optogenetic approach has been developed to model Alzheimer's disease allowing light-induced Amyloid-β aggregation and tested in three model organisms, Drosophila, C. elegans and D. rerio.
    1. Microbiology and Infectious Disease

    Nanoscale organization of rotavirus replication machineries

    Yasel Garcés Suárez et al.
    Super-resolution microscopy reveals, at nanometric-scale, the highly organized protein structure of viroplasms, the viral factories used by rotavirus to replicate its genome and assemble new viral particles.
    1. Stem Cells and Regenerative Medicine

    Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis

    Isabelle Bergiers et al.
    Single-cell transcriptomics analysis identifies the dynamic activity of transcription factors at the onset of hematopoeitic stem and progenitor cells formation during embryonic development.
    1. Cell Biology

    The spatial separation of processing and transport functions to the interior and periphery of the Golgi stack

    Hieng Chiong Tie et al.
    Transport machinery localizes at the cisternal rim while modification machinery localizes at the interior.
    1. Developmental Biology

    A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development

    Christie Ciarlo et al.
    Akt activation is required for neural crest differentiation through regulation of Sox10 activity.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Protein sequences bound to mineral surfaces persist into deep time

    Beatrice Demarchi et al.
    A chemically unstable ostrich eggshell peptide survives for at least 3.8 million years at the equator, stabilized by strong mineral interactions.