144 results found
    1. Structural Biology and Molecular Biophysics

    Structural and functional properties of the transporter SLC26A6 reveal mechanism of coupled anion exchange

    David N Tippett, Colum Breen ... Raimund Dutzler
    The structural and functional characterization of SLC26A6 provides greater understanding of coupled versus uncoupled transport processes for the SLC26 transporter family.
    1. Structural Biology and Molecular Biophysics

    The mechanism of mammalian proton-coupled peptide transporters

    Simon M Lichtinger, Joanne L Parker ... Philip C Biggin
    The manner in which protons control the conformational behaviour of mammalian peptide transporters is revealed through state-of-the-art molecular dynamics simulations supported by cell-based assays.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures and functional characterization of murine Slc26a9 reveal mechanism of uncoupled chloride transport

    Justin D Walter, Marta Sawicka, Raimund Dutzler
    The cryo-EM structure and functional characterization of the chloride-selective ion transporter Slc26a9 defines its oligomeric architecture and transport mechanism.
    1. Chromosomes and Gene Expression

    Serotonin signaling mediates protein valuation and aging

    Jennifer Ro, Gloria Pak ... Scott D Pletcher
    Serotonin modulates diet-dependent lifespan in flies.
    1. Neuroscience

    Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose

    Cheng Qian, Zhaofa Wu ... Yulong Li
    Identification of novel vesicular transporters will shed light on to expanding the chemical diversity of neurotransmitters or neuromodulators.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    A mitochondrial carrier transports glycolytic intermediates to link cytosolic and mitochondrial glycolysis in the human gut parasite Blastocystis

    Eva Pyrihová, Martin S King ... Edmund RS Kunji
    Stramenopiles are unusual, because the pay-off phase of glycolysis occurs in mitochondria rather than the cytosol and the identified mitochondrial carrier links the two parts by transporting glycolytic intermediates.
    1. Neuroscience

    A muscle-epidermis-glia signaling axis sustains synaptic specificity during allometric growth in Caenorhabditis elegans

    Jiale Fan, Tingting Ji ... Daniel A Colón-Ramos
    The work uncovers a muscle-epidermis-glia signaling axis, modulated by protease mig-17 and the basement membrane, that regulates synaptic allometry during growth in Caenorhabditis elegans.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability

    Yilin Kang, Michael James Baker ... Diana Stojanovski
    A novel and metazoan-specific protein, Tim29, is identified as a subunit of the human TIM22 complex and shown to function in the assembly of hTim22 and facilitate contacts with the TOM complex.
    1. Cell Biology
    2. Neuroscience

    Tadr is an axonal histidine transporter required for visual neurotransmission in Drosophila

    Yongchao Han, Lei Peng, Tao Wang
    TADR (torn and diminished rhabdomeres)-dependent histidine transporting is required for de novo synthesis of histamine and for maintaining synaptic transmission of photoreceptor neurons in Drosophila.
    1. Stem Cells and Regenerative Medicine

    Stem cells and fluid flow drive cyst formation in an invertebrate excretory organ

    Hanh Thi-Kim Vu, Jochen C Rink ... Alejandro Sánchez Alvarado
    Planarians provide evidence for a common evolutionary origin of vertebrate and invertebrate excretory systems and provide a novel experimental model to study human kidney diseases.

Refine your results by:

Type
Research categories