284 results found
    1. Neuroscience

    Memory recall involves a transient break in excitatory-inhibitory balance

    Renée S Koolschijn et al.
    Hippocampal activity during memory recall predicts a transient increase in the ratio between neocortical glutamate and GABA, thereby allowing otherwise dormant memories to be released.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Common host variation drives malaria parasite fitness in healthy human red cells

    Emily R Ebel et al.
    Human red blood cells from healthy donors display marked biophysical and genetic variation that impacts the growth of Plasmodium falciparum malaria parasites, outside of known disease alleles.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A modified fluctuation assay reveals a natural mutator phenotype that drives mutation spectrum variation within Saccharomyces cerevisiae

    Pengyao Jiang et al.
    Certain mutational signatures vary in their contribution to genetic variation across the yeast phylogeny due to genetically encoded natural mutator phenotypes whose activity can be directly measured in the lab.
    1. Epidemiology and Global Health

    Telomere length is associated with growth in children in rural Bangladesh

    Audrie Lin et al.
    In a rural, low-income setting in Bangladesh, early-life telomere length was associated with concurrent growth.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Local adaptation and archaic introgression shape global diversity at human structural variant loci

    Stephanie M Yan et al.
    Graph genotyping of structural variation in diverse human populations reveals functional associations and signatures of local adaptation within poorly resolved regions of the genome.
    1. Neuroscience

    Temporo-cerebellar connectivity underlies timing constraints in audition

    Anika Stockert et al.
    With unique lesion-informed tractography, left hemisphere temporo-cerebellar structural connectivity has been established, supporting rapid auditory transmission and cortical functional lateralization.
    1. Microbiology and Infectious Disease

    PGFinder, a novel analysis pipeline for the consistent, reproducible, and high-resolution structural analysis of bacterial peptidoglycans

    Ankur V Patel et al.
    PGFinder is an open-source software dedicated to the analysis of peptidoglycan mass spectrometry data that paves the way for peptidoglycomics.
    1. Evolutionary Biology

    Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies

    Angela M Phillips et al.
    CR9114, one of the most broadly neutralizing anti-influenza antibodies characterized to date, acquires affinity to divergent HA subtypes sequentially, due to higher order interactions between the nested sets of mutations required for binding each distinct subtype.
    1. Neuroscience

    Coupling between motor cortex and striatum increases during sleep over long-term skill learning

    Stefan M Lemke et al.
    Sleep spindles, distinctive brain activity patterns occurring in non-REM sleep, modify cross-area connectivity in the motor network relevant for behavioral flexibility, impacting subsequent behavior.

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