10 results found
    1. Biophysics and Structural Biology
    2. Neuroscience

    Piezo Ion Channels: Portraits of a pressure sensor

    Alexander T Chesler, Marcin Szczot
    Near atomic-resolution structures have provided insights into the mechanisms by which the Piezo1 ion channel senses and responds to mechanical stimuli.
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    1. Neuroscience

    Sparse genetic tracing reveals regionally specific functional organization of mammalian nociceptors

    William Olson et al.
    Single-nociceptor tracing reveals a novel somatotopic organization for the mammalian pain system, and physiological recordings and peripheral optogenetic behavior assays suggest that it is a possible mechanism underlying region-specific pain sensation.
    1. Computational and Systems Biology
    2. Neuroscience

    Olfactory receptor neurons use gain control and complementary kinetics to encode intermittent odorant stimuli

    Srinivas Gorur-Shandilya et al.
    Olfactory receptor neurons adapt to odorant mean and variance and use complementary kinetics to preserve the timing of odorant encounters, despite adaptation slowing down transduction.
    1. Neuroscience

    Semi-intact ex vivo approach to investigate spinal somatosensory circuits

    Junichi Hachisuka et al.
    A new spinal somatosensory preparation is described which enables fine control of sensory input and the ability to manipulate spinal interneurons while recording from spinal projection neurons.
    1. Computational and Systems Biology
    2. Neuroscience

    Decoupling kinematics and mechanics reveals coding properties of trigeminal ganglion neurons in the rat vibrissal system

    Nicholas E Bush et al.
    Primary sensory neurons of the rat whisker system encode contact with objects in terms of the forces exerted on whiskers, rather than the induced whisker movements.
    1. Biophysics and Structural Biology
    2. Neuroscience

    Definition of two agonist types at the mammalian cold-activated channel TRPM8

    Annelies Janssens et al.
    Two natural cooling agents activate the cold-activated channel TRPM8 via two opposite mechanisms, evoking distinct electrical responses in cold-sensitive neurons.
    1. Neuroscience

    Low-noise encoding of active touch by layer 4 in the somatosensory cortex

    Samuel Andrew Hires et al.
    Touch information is represented with minimal noise in the somatosensory cortex during tactile exploration.
    1. Genomics and Evolutionary Biology
    2. Neuroscience

    Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity

    Isaac M Chiu et al.
    Molecular analysis paints a detailed picture of the distinctiveness and complexities of peripheral somatosensory neurons.
    1. Neuroscience

    Vocalization–whisking coordination and multisensory integration of social signals in rat auditory cortex

    Rajnish P Rao et al.
    Snout-to-snout contact modulates the response of rat auditory cortex to calls from other animals, indicating that the multisensory nature of social interaction is directly represented in the rat brain.
    1. Biophysics and Structural Biology
    2. Neuroscience

    Tapered whiskers are required for active tactile sensation

    Samuel Andrew Hires et al.
    The tapered, conical shape of rodent whiskers is essential for sensor mobility in constrained spaces and feature extraction from textured surfaces.

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