170 results found
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers

    Hansen Wang et al.
    The cyclic neuropeptide somatostatin binds to human Aβ1-42 through an interface that critically relies on a specific tryptophan, thereby blocking the propensity of Aβ to aggregate, a critical step in the pathobiology of Alzheimer's disease.
    1. Neuroscience

    Heterogeneous somatostatin-expressing neuron population in mouse ventral tegmental area

    Elina Nagaeva et al.
    The midbrain area for salience, reward and aversion in mouse brain harbours among the dopamine cells three subtypes somatostatin-expressing neurons that show combinatorial neurotransmitter phenotypes and interneuron properties.
    1. Neuroscience

    Somatostatin-positive interneurons in the dentate gyrus of mice provide local- and long-range septal synaptic inhibition

    Mei Yuan et al.
    Somatostatin-expressing interneurons of the rodent dentate gyrus fall into at least two functionally distinct interneuron types with different synaptic integrations into the local dentate gyrus and the more distant medial septum neuronal network.
    1. Neuroscience

    Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network

    Sam A Booker et al.
    Presynaptic GABAB receptors are highly expressed and strongly suppress synaptic transmission at the input and output of hippocampal somatostatin interneurons.
    1. Neuroscience

    Complementary networks of cortical somatostatin interneurons enforce layer specific control

    Alexander Naka et al.
    Subtypes of dendrite-targeting somatostatin cells segregate into separate networks by specifically connecting with neurons in different layers, forming circuits that could independently control different input pathways to the neocortex.
    1. Developmental Biology

    Induction of human somatostatin and parvalbumin neurons by expressing a single transcription factor LIM homeobox 6

    Fang Yuan et al.
    Inducing expression of a single transcription factor LIM homeobox 6 showed efficient generation of human parvalbumin and somatostatin interneurons.
    1. Neuroscience

    An inhibitory corticostriatal pathway

    Crystal Rock et al.
    The discovery of somatostatin-positive inhibitory neurons projecting from mouse cortex to striatum shows that corticostriatal pathways are not exclusively excitatory.
    1. Neuroscience

    Eye opening differentially modulates inhibitory synaptic transmission in the developing visual cortex

    Wuqiang Guan et al.
    Our work demonstrated that eye opening differentially modulates inhibitory synaptic transmission from Sst-INs and FS-INs to excitatory neurons in the mammalian cortex.
    1. Neuroscience

    Complementary control of sensory adaptation by two types of cortical interneurons

    Ryan G Natan et al.
    Two distinct types of inhibitory neurons increase the brain's sensitivity to unexpected acoustic signals by amplifying selective suppression of cortical responses to frequent, but not rare sounds.
    1. Neuroscience

    A neural circuit for gamma-band coherence across the retinotopic map in mouse visual cortex

    Richard Hakim et al.
    A neural circuit between layer 2/3 pyramidal cells and somatostatin-expressing inhibitory neurons synchronizes spatially separated regions of the visual cortex to gamma rhythms.

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