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    1. Neuroscience

    Neural excitability and sensory input determine intensity perception with opposing directions in initial cortical responses

    Tilman Stephani, Alice Hodapp ... Vadim V Nikulin
    Larger evoked responses during initial cortical processing may reflect states of lower excitability.
    1. Cancer Biology
    2. Cell Biology

    The ESRP1-GPR137 axis contributes to intestinal pathogenesis

    Lukas Franz Mager, Viktor Hendrik Koelzer ... Philippe Krebs
    ESRP1 is central to intestinal barrier integrity in mice and humans and alterations in ESRP1 function or expression contribute to intestinal pathology, partly through modified expression of ESRP1-specific GPR137 isoforms.
    1. Neuroscience

    Tuning of motor outputs produced by spinal stimulation during voluntary control of torque directions in monkeys

    Miki Kaneshige, Kei Obara ... Yukio Nishimura
    Spinal stimulation at balanced currents of excitation and inhibition boosts voluntarily produced torque production.
    1. Neuroscience

    Functional abnormalities in the cerebello-thalamic pathways in a mouse model of DYT25 dystonia

    Hind Baba Aïssa, Romain W Sala ... Daniela Popa
    In a mouse model of DYT25 dystonia with disruption of striatal neurotransmission by Gnal mutation, the cerebello-thalamic excitability is increased following symptom expression and θ-burst cerebellar stimulations during cholinergic-induced dystonia depress the cerebello-thalamic transmission and reduce the motor symptom severity.
    1. Neuroscience

    Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors

    Austin R Graves, Richard H Roth ... Richard L Huganir
    A knockin mouse line was made to label endogenous AMPA receptors, enabling direct observation of synaptic plasticity in behaving animals with single-synapse resolution across the entire brain.
    1. Neuroscience

    External location of touch is constructed post-hoc based on limb choice

    Femke Maij, Christian Seegelke ... Tobias Heed
    Humans retrospectively localize touch after deciding on which limb it occurred, challenging the mainstream idea that tactile location in space is the basis for assigning touch to a body part.
    1. Neuroscience

    Frequency-selective control of cortical and subcortical networks by central thalamus

    Jia Liu, Hyun Joo Lee ... Jin Hyung Lee
    Central thalamus relay neurons dynamically switch the activity of cortical and subcortical networks at distinct frequencies, providing a mechanism for this region's role in arousal regulation.
    1. Neuroscience

    Cortical RORβ is required for layer 4 transcriptional identity and barrel integrity

    Erin A Clark, Michael Rutlin ... Sacha B Nelson
    RORβ is a key layer 4 transcription factor orchestrating a critical juncture in barrel development where terminal differentiation and activity inputs are integrated to drive cellular organization in the cortex.
    1. Neuroscience

    A hierarchical, retinotopic proto-organization of the primate visual system at birth

    Michael J Arcaro, Margaret S Livingstone
    A retinotopic proto-organization present at birth provides the infrastructure for the subsequent development of visual cortex that commences at the onset of visual experience.
    1. Neuroscience

    Neural circuitry coordinating male copulation

    Hania J Pavlou, Andrew C Lin ... Stephen F Goodwin
    A circuit consisting of motor neurons, inhibitory interneurons and mechanosensory neurons controls copulatory behaviour in male fruit flies.