927 results found
    1. Cancer Biology
    2. Genetics and Genomics

    Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma

    Jianing Xu, Ed Reznik ... A Ari Hakimi
    A distinct class of kidney tumors is characterized not by patterns of somatic mutations, but by a distinct metabolism.
    1. Neuroscience

    Coherent theta activity in the medial and orbital frontal cortices encodes reward value

    Linda M Amarante, Mark Laubach
    The more you want it or the better it is, the stronger is medial frontal theta (paraphrased from a retweet of the preprint by Dr James Hyman).
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Nanoresolution real-time 3D orbital tracking for studying mitochondrial trafficking in vertebrate axons in vivo

    Fabian Wehnekamp, Gabriela Plucińska ... Don C Lamb
    The ability to follow single objects in 3D in a living organism with high spatiotemporal resolution opens new possibilities for quantitative biophysical studies of complex systems in their physiological context.
    1. Neuroscience

    Orbital frontal cortex updates state-induced value change for decision-making

    Emily T Baltz, Ege A Yalcinbas ... Christina M Gremel
    Orbital frontal cortex projection neuron activity is necessary to update state-dependent value change to control model-based behavior.
    1. Computational and Systems Biology

    Distributing tasks via multiple input pathways increases cellular survival in stress

    Alejandro A Granados, Matthew M Crane ... Peter S Swain
    Single-cell experiments and mathematical modelling show that cellular signalling networks are vulnerable to trade-offs in speed versus accuracy, but that these vulnerabilities can be overcome by distributing the two tasks to different, although interacting, subnetworks.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate

    Natalie A Counihan, Scott A Chisholm ... Tania F de Koning-Ward
    Plasmodium parasites secrete RhopH2 from the rhoptry organelle into their host red blood cell to facilitate the uptake of essential nutrients required for parasite replication and survival.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A glucose-starvation response regulates the diffusion of macromolecules

    Ryan P Joyner, Jeffrey H Tang ... Karsten Weis
    During stress conditions, eukaryotic cells dramatically alter their biophysical properties to regulate diffusion of macromolecules.
    1. Microbiology and Infectious Disease

    Doxycycline has distinct apicoplast-specific mechanisms of antimalarial activity

    Megan Okada, Ping Guo ... Paul A Sigala
    Doxycycline used at a slightly higher concentration kills Plasmodium falciparum malaria parasites with faster, first-cycle activity through a novel organelle-specific mechanism.
    1. Neuroscience

    Cellular cartography of the organ of Corti based on optical tissue clearing and machine learning

    Shinji Urata, Tadatsune Iida ... Shigeo Okabe
    A method of generating comprehensive maps of cochlear cells was created and enabled researchers to study characteristics of cellular damage in aged and noise-exposed inner ear.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Down-regulation of TORC2-Ypk1 signaling promotes MAPK-independent survival under hyperosmotic stress

    Alexander Muir, Françoise M Roelants ... Jeremy Thorner
    Building on previous work (Muir et al., 2014), we validate the utility of a screen for new protein kinase substrates and define the underlying molecular basis of a new mechanism for responding to hypertonic conditions.

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