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    1. Microbiology and Infectious Disease
    2. Cell Biology

    The Plasmodium falciparum rhoptry protein RhopH3 plays essential roles in host cell invasion and nutrient uptake

    Emma S Sherling, Ellen Knuepfer ... Christiaan van Ooij
    The rhoptry protein RhopH3 is crucial for the invasion and growth of the malaria parasite and disruption of it provides insight into the binding of the parasite to the host red blood cell and into the formation of new import pathways.
    1. Neuroscience

    Neural mechanisms of economic choices in mice

    Masaru Kuwabara, Ningdong Kang ... Camillo Padoa-Schioppa
    Inactivation of the lateral orbital area disrupts economic choice behavior and neurons in this area encode the value of offered and chosen options.
    1. Physics of Living Systems

    Control of nuclear size by osmotic forces in Schizosaccharomyces pombe

    Joël Lemière, Paula Real-Calderon ... Fred Chang
    The volume of the nucleus is dictated by a balance of colloid osmotic forces from the nucleoplasm and cytoplasm.
    1. Cell Biology

    A pH-driven transition of the cytoplasm from a fluid- to a solid-like state promotes entry into dormancy

    Matthias Christoph Munder, Daniel Midtvedt ... Simon Alberti
    The cytoplasm behaves as an adaptable fluid that can reversibly transition into a protective solid-like state upon stress.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Yeast cell responses and survival during periodic osmotic stress are controlled by glucose availability

    Fabien Duveau, Céline Cordier ... Pascal Hersen
    Microfluidic methods are used to quantitatively probe single yeast cells' response to either simultaneous or sequential stresses, revealing the dynamic interplay between two antagonistic inputs, osmotic stress and glucose starvation.
    1. Neuroscience

    Drosophila HCN mediates gustatory homeostasis by preserving sensillar transepithelial potential in sweet environments

    MinHyuk Lee, Se Hoon Park ... KyeongJin Kang
    A hyperpolarization-activated cation channel, counteracting membrane depolarization, delimits the excitability of receptor neurons subjected to naturally prolonged stimulation to preserve the function of neighboring receptor neurons in Drosophila gustation.
    1. Neuroscience

    Mechanism for differential recruitment of orbitostriatal transmission during actions and outcomes following chronic alcohol exposure

    Rafael Renteria, Christian Cazares ... Christina M Gremel
    Chronic alcohol exposure results in a long-lasting, enhanced endocannabinoid signalling at orbitostriatal synapses that is expressed in a projection-, synapse-, and behaviorally computation-specific manner.
    1. Neuroscience

    A single pair of pharyngeal neurons functions as a commander to reject high salt in Drosophila melanogaster

    Jiun Sang, Subash Dhakal ... Youngseok Lee
    Fruit flies have special neurons in their pharynx with ionotropic receptors to prevent consuming too much salt, which was confirmed using a variety of behavioral and physiological assays.
    1. Cell Biology
    2. Neuroscience

    Cumulative mitochondrial activity correlates with ototoxin susceptibility in zebrafish mechanosensory hair cells

    Sarah B Pickett, Eric D Thomas ... David W Raible
    The history of mitochondrial activity predicts whether zebrafish mechanosensory hair cells live or die after toxic drug exposure.
    1. Neuroscience

    Lateral orbitofrontal cortex promotes trial-by-trial learning of risky, but not spatial, biases

    Christine M Constantinople, Alex T Piet ... Carlos D Brody
    The lateral orbitofrontal cortex promotes learning of abstract, task-specific biases, but not spatial ones.