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    1. Computational and Systems Biology
    2. Neuroscience

    Theoretical relation between axon initial segment geometry and excitability

    Sarah Goethals, Romain Brette
    Theoretical analysis uncovers the impact of axon initial segment plasticity on neural excitability.
    1. Neuroscience

    Influence of sensory modality and control dynamics on human path integration

    Akis Stavropoulos, Kaushik J Lakshminarasimhan ... Dora E Angelaki
    Human path integration accuracy is strongly influenced by the underlying control dynamics, but less so when visual, rather than vestibular, feedback is available.
    1. Neuroscience

    Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation

    Ryszard Stefan Gomolka, Lauren M Hablitz ... Yuki Mori
    Mice with aquaporin-4 channel deletion exhibit larger interstitial spaces, brain volume and water content, alongside reduced CSF space volume, which may increased resistance towards brain fluid efflux and suppress glymphatic flow.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structural basis for the hijacking of endosomal sorting nexin proteins by Chlamydia trachomatis

    Blessy Paul, Hyun Sung Kim ... Brett M Collins
    Chlamydia hijacks membrane trafficking proteins of the human host via the cytoplasmic domain of a secreted transmembrane protein.
    1. Chromosomes and Gene Expression

    Nup98-dependent transcriptional memory is established independently of transcription

    Pau Pascual-Garcia, Shawn C Little, Maya Capelson
    Transcription and epigenetic memory of transcription are two co-occurring independent pathways, governed by different rate constants and unique parameters.
    1. Computational and Systems Biology
    2. Neuroscience

    Visuomotor learning from postdictive motor error

    Jana Masselink, Markus Lappe
    Visual, motor, and forward model gains learn from a postdictive update of space to keep perception and saccadic motor function aligned.
    1. Physics of Living Systems
    2. Computational and Systems Biology

    Global morphogenetic flow is accurately predicted by the spatial distribution of myosin motors

    Sebastian J Streichan, Matthew F Lefebvre ... Boris I Shraiman
    Epithelial tissue remodeling during Drosophila embryonic development is quantitatively described by a simple law relating myosin activity and cell flow.
    1. Ecology
    2. Physics of Living Systems

    Microbial consortia at steady supply

    Thibaud Taillefumier, Anna Posfai ... Ned S Wingreen
    In a consumer-resource model obeying the physical requirement of flux conservation, metabolic competition between microbes yields consortia of cell types that collectively resist invasion via optimal use of resources.
    1. Neuroscience

    Population codes enable learning from few examples by shaping inductive bias

    Blake Bordelon, Cengiz Pehlevan
    Neural sensory representations impose an inductive bias over the space of learning tasks, allowing some tasks to be learned by a downstream neuron more sample-efficiently than others.
    1. Neuroscience

    Global sleep homeostasis reflects temporally and spatially integrated local cortical neuronal activity

    Christopher W Thomas, Mathilde CC Guillaumin ... Vladyslav V Vyazovskiy
    The global sleep homeostatic process tracks sleep-wake history by integrating local cortical neuronal activity over time and space, rather than directly reflecting changes in specific homeostatically regulated physiological variables.