3,741 results found
    1. Cell Biology
    2. Developmental Biology

    LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome

    Laura Bozal-Basterra et al.
    LUZP1 is required for proper cilia and cytoskeleton formation.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA

    Flora S Groothuizen et al.
    Visualization of the sliding clamp in DNA mismatch repair shows how a transient complex is activated.
    1. Developmental Biology
    2. Evolutionary Biology

    Developmental hourglass and heterochronic shifts in fin and limb development

    Koh Onimaru et al.
    Omics approaches reveal conserved and diversified gene regulation between fin and limb development.
    1. Chromosomes and Gene Expression

    Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity

    Jeffrey M Alexander et al.
    Sox2 transcription is not correlated with spatial proximity of its essential regulatory enhancer in embryonic stem cells, suggesting gene transcription is not limited to periods of direct enhancer-promoter contact.
    1. Developmental Biology
    2. Genetics and Genomics

    Molecular shifts in limb identity underlie development of feathered feet in two domestic avian species

    Eric T Domyan et al.
    Feathered feet of pigeons and chickens result from a partial molecular and morphological transformation of legs to a wing-like identity.
    1. Cell Biology

    Sphingomyelin metabolism controls the shape and function of the Golgi cisternae

    Felix Campelo et al.
    Association of curvature generating proteins to the Golgi membranes by sphingomyelin metabolism essentially controls the flatness of a Golgi cisterna that is necessary for efficient sorting and export.
    1. Ecology
    2. Genetics and Genomics

    Education and Outreach: March Mammal Madness and the power of narrative in science outreach

    Katie Hinde et al.
    Hypothetical battles between animals can be used to interest the general public in biology.
    1. Computational and Systems Biology
    2. Medicine

    SARS-CoV-2 strategically mimics proteolytic activation of human ENaC

    Praveen Anand et al.
    SARS-CoV-2 has evolved to cleverly mimic the FURIN-cleavage site in human ENaC-α, unlike any prior coronavirus strain, shedding new light on the Acute Respiratory Distress Syndrome (ARDS) in COVID-19 patients.
    1. Epidemiology and Global Health

    National and regional seasonal dynamics of all-cause and cause-specific mortality in the USA from 1980 to 2016

    Robbie M Parks et al.
    All parts of the USA are similarly adapted to temperature seasonality, although mortality seasonality, and how it has changed since the 1980s, depend on age and sex.
    1. Genetics and Genomics

    Codon optimization underpins generalist parasitism in fungi

    Thomas Badet et al.
    Codon optimization through biased synonymous substitutions is a characteristic feature of the genomes of generalist fungal parasites and is associated with the colonization of multiple hosts.

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