1,004 results found
    1. Neuroscience

    A spatial memory signal shows that the parietal cortex has access to a craniotopic representation of space

    Mulugeta Semework et al.
    Neural recordings and analyses illustrate a unique lateral intraparietal area (LIP) response that may contribute to how primates can establish a memory of the environment in a useful coordinate frame, and maintain this representation of the environment over time.
    1. Cell Biology
    2. Neuroscience

    Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory

    Yang Niu et al.
    SNX6 regulates the distribution of a protein called Homer1b/c to distal dendrites, enabling the latter to stabilize the synapses and thereby support memory formation.
    1. Neuroscience

    A neural-level model of spatial memory and imagery

    Andrej Bicanski, Neil Burgess
    The BB model explains spatial cognition in terms of interactions between specific neuronal populations, providing a common computational framework for the human neuropsychological and in vivo animal electrophysiological literatures.
    1. Neuroscience

    Dissociated sequential activity and stimulus encoding in the dorsomedial striatum during spatial working memory

    Hessameddin Akhlaghpour et al.
    During a spatial working memory task, neurons in the dorsomedial striatum encode the sample stimulus most strongly towards the onset of the delay period, while they display sequential firing activity that more evenly spans the delay period.
    1. Neuroscience

    Social observation enhances cross-environment activation of hippocampal place cell patterns

    Xiang Mou, Daoyun Ji
    Place cells associated with track-running are activated in rats staying in a nearby box while another rat running on the track, suggesting that social observation facilitates spatial memory representations.
    1. Neuroscience

    Impaired spatial memory codes in a mouse model of Rett syndrome

    Sara E Kee et al.
    Hypersynchrony in a mouse model of Rett syndrome impairs ripple-dependent memory consolidation and leads to a decrease in experience-dependent refinement of place cell activities.
    1. Neuroscience

    Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice

    Panayiotis Tsokas et al.
    The enzyme PKMzeta is crucial for the maintenance of long-term memories, but a closely related enzyme provides a back-up should PKMzeta fail, thus explaining the controversy over why deleting the gene for PKMzeta may not appear to impair memory.
    1. Neuroscience

    Rigid firing sequences undermine spatial memory codes in a neurodegenerative mouse model

    Jingheng Cheng, Daoyun Ji
    In a mouse model of neurodegeneration, hippocampal firing sequences that normally encode spatial memories become disengaged from external space.
    1. Neuroscience

    Navigation: Shedding light on stellate cells

    Andrew S Alexander, Michael E Hasselmo
    The relationship between grid cells and two types of neurons found in the medial entorhinal cortex has been clarified.
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    1. Neuroscience

    Experience-dependent shaping of hippocampal CA1 intracellular activity in novel and familiar environments

    Jeremy D Cohen et al.
    Comparison of the intracellular activity of hippocampal neurons in novel and familiar environments reveals experience-dependent changes in inputs underlying the formation of stable representations of space.

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