2,529 results found
    1. Cell Biology

    Spatial organization shapes the turnover of a bacterial transcriptome

    Jeffrey R Moffitt et al.
    Transcriptome-scale RNA imaging and lifetime measurements reveal that the E. coli transcriptome is spatially organized and that this organization modulates the post-transcriptional fate of bacterial mRNAs.
    1. Cell Biology

    Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension

    Joanna P Rys et al.
    Cells control the spatial organization and signaling of TGFβ receptors at focal adhesions via a mechanically regulated mechanism to integrate biochemical and physical cues.
    1. Ecology

    Spatial self-organization favors heterotypic cooperation over cheating

    Babak Momeni et al.
    Two cooperative populations of yeast cells that cannot distinguish between cooperative partners and cheating intruders can still self-organize into clusters that exclude cheaters.
    1. Neuroscience

    Cellular taxonomy and spatial organization of the murine ventral posterior hypothalamus

    Laura E Mickelsen et al.
    Single cell RNA–sequencing and neuroanatomical methods reveal unexpected molecular diversity and highly segregated spatial organization of neuronal cell types within the mouse ventral posterior hypothalamus, including the mammillary nuclei.
    1. Neuroscience

    Multi-scale mapping along the auditory hierarchy using high-resolution functional UltraSound in the awake ferret

    Célian Bimbard et al.
    Functional UltraSound imaging allows mapping tonotopic organisation in multiple auditory subcortical and cortical brain structures with an unprecedented spatial functional resolution, while giving access to long-distance top-down connectivity pattern from frontal cortex to auditory cortex.
    1. Physics of Living Systems

    A minimal self-organisation model of the Golgi apparatus

    Quentin Vagne et al.
    An unbiased model for the self-organisation of the Golgi apparatus displays either anterograde vesicular transport or cisternal maturation depending on ratios of budding, fusion and biochemical conversion rates.
    1. Microbiology and Infectious Disease

    Nanoscale organization of rotavirus replication machineries

    Yasel Garcés Suárez et al.
    Super-resolution microscopy reveals, at nanometric-scale, the highly organized protein structure of viroplasms, the viral factories used by rotavirus to replicate its genome and assemble new viral particles.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Influenza A virus surface proteins are organized to help penetrate host mucus

    Michael D Vahey, Daniel A Fletcher
    By distributing receptor-binding and receptor-destroying proteins asymmetrically on their surface, filamentous influenza A virus particles create a Brownian ratchet that facilitates their passage through mucus.
    1. Epidemiology and Global Health

    Global mapping of highly pathogenic avian influenza H5N1 and H5Nx clade 2.3.4.4 viruses with spatial cross-validation

    Madhur S Dhingra et al.
    The global suitability for avian flu H5N1 in poultry is predicted and spatially cross-validated, highlighting areas where the disease can spread in the absence of prevention and control, and represent a public health threat.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Metagenomic chromosome conformation capture (meta3C) unveils the diversity of chromosome organization in microorganisms

    Martial Marbouty et al.
    A technique called meta3C provides an elegant and integrated approach to metagenomic analysis by allowing the de novo assembly, scaffolding and 3D characterization of unknown genomes from a complex mix of species

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