1,849 results found
    1. Neuroscience

    How spatial release from masking may fail to function in a highly directional auditory system

    Norman Lee, Andrew C Mason
    The auditory periphery of Ormia ochracea does not allow for spatial release from masking.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Organic electrochemical transistor arrays for real-time mapping of evoked neurotransmitter release in vivo

    Kai Xie, Naixiang Wang ... Peng Shi
    An implantable device based on organic electrochemical transistors is developed for quantitative mapping of neurotransmitter release across multiple brain regions, revealing a cross-talk between the mesolimbic and nigrostriatal dopaminergic pathways.
    1. Neuroscience

    Spatiotemporal dynamics of multi-vesicular release is determined by heterogeneity of release sites within central synapses

    Dario Maschi, Vitaly A Klyachko
    Release site heterogeneity represents a previously unknown level of structural and functional organization within individual active zones in central synapses, which determines the spatiotemporal dynamics of multi-vesicular release.
    1. Computational and Systems Biology
    2. Neuroscience

    Mapping nonlinear receptive field structure in primate retina at single cone resolution

    Jeremy Freeman, Greg D Field ... EJ Chichilnisky
    Multi-electrode recordings and modeling are combined to reveal the transformations of signals from cones to bipolar cells and then to ganglion cells within the primate retina.
    1. Neuroscience

    Two forms of asynchronous release with distinctive spatiotemporal dynamics in central synapses

    Gerardo Malagon, Jongyun Myeong, Vitaly A Klyachko
    Asynchronous release is not uniform, but comprises two subpopulations of events, one occurring inside the active zone and another occurring ectopically, which are characterized by distinctive spatiotemporal dynamics in hippocampal synapses.
    1. Developmental Biology
    2. Physics of Living Systems

    Controlling periodic long-range signalling to drive a morphogenetic transition

    Hugh Z Ford, Angelika Manhart, Jonathan R Chubb
    Cells control signal circulation to set the frequency of information transmitted over tissue scales.
    1. Neuroscience

    Targeted sensors for glutamatergic neurotransmission

    Yuchen Hao, Estelle Toulmé ... Andrew JR Plested
    Targeting a genetically-encoded glutamate sensor to postsynaptic sites demonstrates the feasibility of simultaneous optical quantal analysis of many inputs to a neuron in wide-field fluorescence microscopy.
    1. Neuroscience

    Visualizing synaptic dopamine efflux with a 2D composite nanofilm

    Chandima Bulumulla, Andrew T Krasley ... Abraham G Beyene
    A technology for measuring release of dopamine simultaneously from hundreds of release sites at the spatial resolution of a synapse is provided.
    1. Neuroscience

    Septal cholinergic input to CA2 hippocampal region controls social novelty discrimination via nicotinic receptor-mediated disinhibition

    Domenico Pimpinella, Valentina Mastrorilli ... Marilena Griguoli
    Acetylcholine, released from cholinergic fibers originating from the medial septum, shapes social memory, and controls the CA2 hippocampal circuit via nicotinic receptors localized on GABAergic interneurons.
    1. Neuroscience

    The inhibitory microcircuit of the substantia nigra provides feedback gain control of the basal ganglia output

    Jennifer Brown, Wei-Xing Pan, Joshua Tate Dudman
    Negative feedback signals within the substantia nigra regulate the output of the basal ganglia, with implications for disorders such as Parkinson's disease.

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