4,063 results found
    1. Computational and Systems Biology
    2. Medicine

    An integrative model of cardiometabolic traits identifies two types of metabolic syndrome

    Amit Frishberg et al.
    A novel type of metabolic syndrome, derived from computational modeling of phenotypic diversity in normal physiological settings, increases the risk of certain complex diseases.
    1. Developmental Biology
    2. Neuroscience

    Dual midbrain and forebrain origins of thalamic inhibitory interneurons

    Polona Jager et al.
    Thalamic interneurons in the mouse thalamus are often overlooked because of their extremely low numbers, however they are developmentally complex and related to those of larger-brained species.
    1. Stem Cells and Regenerative Medicine

    Heterogeneity of murine periosteum progenitors involved in fracture healing

    Brya G Matthews et al.
    Murine periosteum is highly enriched for osteoprogenitors, many of which express αSMA, but fracture callus chondrocytes are partially derived from other sources.
    1. Plant Biology

    A multifaceted analysis reveals two distinct phases of chloroplast biogenesis during de-etiolation in Arabidopsis

    Rosa Pipitone et al.
    Serial-Block-Face Scanning Electron Microscopy (SBF-SEM) associated with biomolecular analysis show that chloroplast differentiation proceeds by distinct ‘structure establishment’ and ‘chloroplast proliferation’ phases, each with differential protein and lipid regulation.
    1. Biochemistry and Chemical Biology

    Identification of host proteins differentially associated with HIV-1 RNA splice variants

    Rachel Knoener et al.
    The distinct protein-RNA interactomes of HIV-1 RNA splice forms are revealed using a powerful multiplex strategy for RNA capture and mass spectrometric analysis.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    An interbacterial DNA deaminase toxin directly mutagenizes surviving target populations

    Marcos H de Moraes et al.
    Interbacterial interactions can promote mutagenesis, and possibly adaptation, when intoxicated cells survive exposure to type VI secretion-delivered DNA deaminase toxins.
    1. Cell Biology

    In vivo proteomic mapping through GFP-directed proximity-dependent biotin labelling in zebrafish

    Zherui Xiong et al.
    BLITZ system enables proximity-dependent biotin labelling in live zebrafish embryos with cell and tissue specificity, providing a versatile and valuable tool for proteomic discovery using the zebrafish model.
    1. Cancer Biology
    2. Genetics and Genomics

    Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells

    Iris E Glykofridis et al.
    Knocking out Folliculin (FLCN) in human renal epithelial cells activates STAT1/2-mediated gene expression, independent of interferon, uncovering a tissue-specific process potentially relevant in the cancer syndrome Birt-Hogg-Dubé (BHD).
    1. Neuroscience

    A prefrontal-bed nucleus of the stria terminalis circuit limits fear to uncertain threat

    Lucas R Glover et al.
    A neural circuit between the prefrontal cortex and bed nucleus of the stria terminalis is shown to limit fear to cues that only partially associate with threat.
    1. Ecology
    2. Genetics and Genomics

    Education and Outreach: March Mammal Madness and the power of narrative in science outreach

    Katie Hinde et al.
    Hypothetical battles between animals can be used to interest the general public in biology.

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