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    1. Neuroscience

    Spatial modulation of visual responses arises in cortex with active navigation

    E Mika Diamanti, Charu Bai Reddy ... Matteo Carandini
    Spatial modulation along the visual pathway arises in the cortex and strengthens with active navigation and experience.
    1. Neuroscience

    Numerical magnitude, rather than individual bias, explains spatial numerical association in newborn chicks

    Rosa Rugani, Giorgio Vallortigara ... Lucia Regolin
    Spatial numerical association in three-day-old domestic chicks linearly decreases as numerical magnitude increases (2>5>8), supporting the hypothesis that numerical magnitude guides the spatial numerical association.
    1. Immunology and Inflammation
    2. Neuroscience

    Spatial transcriptomics of meningeal inflammation reveals inflammatory gene signatures in adjacent brain parenchyma

    Sachin P Gadani, Saumitra Singh ... Pavan Bhargava
    Leptomeningeal inflammation in a mouse model of multiple sclerosis triggers deeply penetrating gene changes in underlying brain tissue, described using spatial transcriptomics.
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    1. Computational and Systems Biology
    2. Genetics and Genomics

    Spotless, a reproducible pipeline for benchmarking cell type deconvolution in spatial transcriptomics

    Chananchida Sang-aram, Robin Browaeys ... Yvan Saeys
    Estimating cell type composition from a gene expression mixture remains a challenging task, as evidenced by how a simple regression model outperforms many state-of-the-art spatial deconvolution methods.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex

    Dipak N Patil, Erumbi S Rangarajan ... Kirill A Martemyanov
    Atomic details on structural organization and conformational dynamics of the key regulator of neuronal signaling shed light on its allosteric regulation and role in regulating cellular pathways.
    1. Computational and Systems Biology
    2. Medicine

    Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury

    Lilija Wehling, Liam Keegan ... Kai Breuhahn
    Nuclear phosphorylation differentially controls the activity of Hippo pathways effectors YAP and TAZ via distinct molecular mechanisms under physiological and tissue damage conditions.
    1. Cell Biology
    2. Genetics and Genomics

    Spatial transcriptomic and single-nucleus analysis reveals heterogeneity in a gigantic single-celled syncytium

    Tobias Gerber, Cristina Loureiro ... J Gray Camp
    Nuclei of the true slime mold Physarum polycephalum are continuously shuttled within the cytoplasmic flow across the gigantic syncytium, yet Physarum can establish and maintain gene expression heterogeneity between different structures of the organism.
    1. Cell Biology

    Spatial transcriptomics reveals metabolic changes underly age-dependent declines in digit regeneration

    Robert J Tower, Emily Busse ... Mimi C Sammarco
    Metabolic supplementation attenuates age-dependent declines in regeneration.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Spatial alanine metabolism determines local growth dynamics of Escherichia coli colonies

    Francisco Díaz-Pascual, Martin Lempp ... Knut Drescher
    An investigation of spatiotemporal metabolic differentiation during colony biofilm growth of E. coli revealed that alanine is cross-fed between spatially segregated subpopulations within the colony, to support cellular growth in an otherwise nutrient-deprived region of the colony.
    1. Cell Biology
    2. Computational and Systems Biology

    Spatially coordinated dynamic gene transcription in living pituitary tissue

    Karen Featherstone, Kirsty Hey ... Julian RE Davis
    Quantitative statistical modelling reveals local coordination of stochastic gene transcription dynamics in pituitary tissue, which is relevant for integrated tissue responses to physiological stimuli.