Rosa Rugani, Giorgio Vallortigara ... Lucia Regolin
Spatial numerical association in three-day-old domestic chicks linearly decreases as numerical magnitude increases (2>5>8), supporting the hypothesis that numerical magnitude guides the spatial numerical association.
Sachin P Gadani, Saumitra Singh ... Pavan Bhargava
Leptomeningeal inflammation in a mouse model of multiple sclerosis triggers deeply penetrating gene changes in underlying brain tissue, described using spatial transcriptomics.
Chananchida Sang-aram, Robin Browaeys ... Yvan Saeys
Estimating cell type composition from a gene expression mixture remains a challenging task, as evidenced by how a simple regression model outperforms many state-of-the-art spatial deconvolution methods.
Dipak N Patil, Erumbi S Rangarajan ... Kirill A Martemyanov
Atomic details on structural organization and conformational dynamics of the key regulator of neuronal signaling shed light on its allosteric regulation and role in regulating cellular pathways.
Nuclear phosphorylation differentially controls the activity of Hippo pathways effectors YAP and TAZ via distinct molecular mechanisms under physiological and tissue damage conditions.
Nuclei of the true slime mold Physarum polycephalum are continuously shuttled within the cytoplasmic flow across the gigantic syncytium, yet Physarum can establish and maintain gene expression heterogeneity between different structures of the organism.
Francisco Díaz-Pascual, Martin Lempp ... Knut Drescher
An investigation of spatiotemporal metabolic differentiation during colony biofilm growth of E. coli revealed that alanine is cross-fed between spatially segregated subpopulations within the colony, to support cellular growth in an otherwise nutrient-deprived region of the colony.
Karen Featherstone, Kirsty Hey ... Julian RE Davis
Quantitative statistical modelling reveals local coordination of stochastic gene transcription dynamics in pituitary tissue, which is relevant for integrated tissue responses to physiological stimuli.