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    1. Cell Biology

    Cortical dynein pulling mechanism is regulated by differentially targeted attachment molecule Num1

    Safia Omer et al.
    Dynein-dependent microtubule-cortex interactions – "side-on" versus "end-on" pulling – are regulated by cortical ER and mediated by distinct pools of cortical anchor that are differentially localized along the cell periphery.
    1. Cell Biology

    β-blockers augment L-type Ca2+ channel activity by targeting spatially restricted β2AR signaling in neurons

    Ao Shen et al.
    FRET biosensor-based measurement of cAMP signaling and single-channel recording reveal that β-blockers trigger local activation of adrenergic receptors and calcium channels in primary neurons.
    1. Neuroscience

    Recurrent network model for learning goal-directed sequences through reverse replay

    Tatsuya Haga, Tomoki Fukai
    The combination of short-term and long-term plasticity enables hippocampus to learn goal-directed paths through replay in a reversed order.
    1. Neuroscience

    Activities of visual cortical and hippocampal neurons co-fluctuate in freely moving rats during spatial behavior

    Daniel Christopher Haggerty, Daoyun Ji
    As rats learn to traverse back and forth on a track, visual cortical neurons fire at specific locations and functionally interact with those hippocampal place cells representing the same locations.
    1. Neuroscience

    Spatial readout of visual looming in the central brain of Drosophila

    Mai M Morimoto et al.
    In the Drosophila central brain, synaptic connectivity extracts visual-spatial information from the axons of looming sensitive LC6 neurons that terminate in a glomerulus with minimal retinotopy.
    1. Neuroscience

    Three rules govern thalamocortical connectivity of fast-spike inhibitory interneurons in the visual cortex

    Yulia Bereshpolova et al.
    In the visual system, three rules guide the thalamocortical connectivity of cortical fast-spike interneurons and are key to understand the potent and broadly tuned feed-forward inhibition that they generate.
    1. Neuroscience

    Synchronous activity patterns in the dentate gyrus during immobility

    Martin Pofahl et al.
    Two-photon in vivo calcium imaging reveals short time-scale, synchronous and sparse population activity in dentate gyrus that replays place-related information, and is important for formation of dentate-dependent spatial memory.
    1. Developmental Biology
    2. Neuroscience

    Glial insulin regulates cooperative or antagonistic Golden goal/Flamingo interactions during photoreceptor axon guidance

    Hiroki Takechi et al.
    Timely regulation of growth cone dynamics, including filopodial and cytoskeletal rearrangements through phosphorylation signals from glial cells, shapes the photoreceptor axon targeting.
    1. Developmental Biology

    A gradient of Wnt activity positions the neurosensory domains of the inner ear

    Magdalena Żak, Nicolas Daudet
    Manipulations of Wnt signalling in the chicken embryo reveal how it controls in a dose-dependent manner the formation of the neurosensory territories of the early developing inner ear.
    1. Microbiology and Infectious Disease

    Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest

    Sara Marelli et al.
    Systematic screen of HIV-1 Vif mutants identifies synthetic and naturally occurring amino acid polymorphisms separating PPP2R5 and APOBEC3 family protein depletion and uncovers the mechanism of Vif-dependent cell cycle arrest.