Christopher M Ciarleglio, Arseny S Khakhalin ... Carlos D Aizenman
The diversity of electrophysiological phenotypes of neurons in a functional network increases over development, but can be modulated, and even reduced by sensory experience; allowing them to adapt to a changing and growing brain.
The NDNF-like factor Nord is a Hedgehog-induced and extracellular-localized dosage-dependent BMP modulator that regulates Drosophila wing patterning and growth.
Carolyn Elya, Danylo Lavrentovich ... Benjamin de Bivort
In zombie fruit flies, Entomophthora muscae-elicited summiting behavior is mediated by blood-borne factors and the host circadian-neurosecretory network.
Spinal dI2 interneurons relay peripheral and intraspinal feedback to premotor networks in the spinal cord and the cerebellum to ensure the stability of bipedal stepping.
Bradley M Colquitt, Kelly Li ... Michael S Brainard
Large-scale gene expression analysis of the songbird brain identifies the molecular and cellular features of vocal motor circuits that are altered by the loss of hearing.
Marija Markicevic, Oliver Sturman ... Nicole Wenderoth
The structural characteristics of a circuit and its hierarchical dimensions are shown to influence regional time-series dynamics after targeted cellular-level manipulations.
Alice L Herneisen, Michelle L Peters ... Sebastian Lourido
Genetic and proteomic analyses reveal that the SPARK kinase, which is a regulator of key life-cycle transitions in the parasite Toxoplasma gondii, complexes with an elongin-like protein to regulate several important AGC-family kinases.
Endothelial cells from separate cardiac lineages start off in distinct transcriptional states, but over the course of development converge into transcriptional and functional states which are unrelated to lineage and which are conserved between mouse and human.
A previously unknown calcium channel in human placental trophoblasts provides a calcium source for activating TMEM16F lipid scramblase that flip-flops phospholipids on cell surface, demonstrating a physiological mechanism that helps to understand how lipid dynamics regulates cell fusion.