126 results found
    1. Neuroscience

    Multivariate analysis of electrophysiological diversity of Xenopus visual neurons during development and plasticity

    Christopher M Ciarleglio, Arseny S Khakhalin ... Carlos D Aizenman
    The diversity of electrophysiological phenotypes of neurons in a functional network increases over development, but can be modulated, and even reduced by sensory experience; allowing them to adapt to a changing and growing brain.
    1. Cell Biology
    2. Developmental Biology

    The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth

    Shu Yang, Xuefeng Wu ... Xiaoyan Zheng
    The NDNF-like factor Nord is a Hedgehog-induced and extracellular-localized dosage-dependent BMP modulator that regulates Drosophila wing patterning and growth.
    1. Genetics and Genomics
    2. Neuroscience

    Neural mechanisms of parasite-induced summiting behavior in ‘zombie’ Drosophila

    Carolyn Elya, Danylo Lavrentovich ... Benjamin de Bivort
    In zombie fruit flies, Entomophthora muscae-elicited summiting behavior is mediated by blood-borne factors and the host circadian-neurosecretory network.
    1. Developmental Biology
    2. Neuroscience

    Spinal lumbar dI2 interneurons contribute to stability of bipedal stepping

    Baruch Haimson, Yoav Hadas ... Avihu Klar
    Spinal dI2 interneurons relay peripheral and intraspinal feedback to premotor networks in the spinal cord and the cerebellum to ensure the stability of bipedal stepping.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Neural circuit-wide analysis of changes to gene expression during deafening-induced birdsong destabilization

    Bradley M Colquitt, Kelly Li ... Michael S Brainard
    Large-scale gene expression analysis of the songbird brain identifies the molecular and cellular features of vocal motor circuits that are altered by the loss of hearing.
    1. Developmental Biology
    2. Evolutionary Biology

    Cortex cis-regulatory switches establish scale colour identity and pattern diversity in Heliconius

    Luca Livraghi, Joseph J Hanly ... Chris D Jiggins
    The evolution of a butterfly mimetic phenotype is driven by modular cis-regulstory switches controlling a ‘hotspot’ gene.
    1. Neuroscience

    Neuromodulation of striatal D1 cells shapes BOLD fluctuations in anatomically connected thalamic and cortical regions

    Marija Markicevic, Oliver Sturman ... Nicole Wenderoth
    The structural characteristics of a circuit and its hierarchical dimensions are shown to influence regional time-series dynamics after targeted cellular-level manipulations.
    1. Microbiology and Infectious Disease

    SPARK regulates AGC kinases central to the Toxoplasma gondii asexual cycle

    Alice L Herneisen, Michelle L Peters ... Sebastian Lourido
    Genetic and proteomic analyses reveal that the SPARK kinase, which is a regulator of key life-cycle transitions in the parasite Toxoplasma gondii, complexes with an elongin-like protein to regulate several important AGC-family kinases.
    1. Developmental Biology

    Coronary blood vessels from distinct origins converge to equivalent states during mouse and human development

    Ragini Phansalkar, Josephine Krieger ... Kristy Red-Horse
    Endothelial cells from separate cardiac lineages start off in distinct transcriptional states, but over the course of development converge into transcriptional and functional states which are unrelated to lineage and which are conserved between mouse and human.
    1. Cell Biology

    Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion

    Yang Zhang, Pengfei Liang ... Huanghe Yang
    A previously unknown calcium channel in human placental trophoblasts provides a calcium source for activating TMEM16F lipid scramblase that flip-flops phospholipids on cell surface, demonstrating a physiological mechanism that helps to understand how lipid dynamics regulates cell fusion.

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