1,558 results found
    1. Developmental Biology

    A spatiotemporal reconstruction of the C. elegans pharyngeal cuticle reveals a structure rich in phase-separating proteins

    Muntasir Kamal, Levon Tokmakjian ... Peter J Roy
    A meta-analysis yields a spatiotemporal map of gene expression that provides a blueprint for nematode cuticle construction and reveals novel families of cuticular intrinsically disordered proteins.
    1. Neuroscience

    Two forms of asynchronous release with distinctive spatiotemporal dynamics in central synapses

    Gerardo Malagon, Jongyun Myeong, Vitaly A Klyachko
    Asynchronous release is not uniform, but comprises two subpopulations of events, one occurring inside the active zone and another occurring ectopically, which are characterized by distinctive spatiotemporal dynamics in hippocampal synapses.
    1. Neuroscience

    Spatiotemporal organisation of human sensorimotor beta burst activity

    Catharina Zich, Andrew J Quinn ... Sven Bestmann
    Burst activity can be described in all three signal domains and sensorimotor beta burst activity propagates along two axes either parallel or perpendicular to the central sulcus.
    1. Neuroscience

    Spatiotemporally precise optogenetic activation of sensory neurons in freely walking Drosophila

    Brian D DeAngelis, Jacob A Zavatone-Veth ... Damon A Clark
    A simple, computationally efficient method provides spatiotemporally precise optogenetic perturbations in freely walking Drosophila, revealing the asymmetries and region-specificity of behavioral programs evoked by activating mechanosensory and chemosensory neurons.
    1. Computational and Systems Biology
    2. Developmental Biology

    Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration

    Emanuel Cura Costa, Leo Otsuki ... Osvaldo Chara
    Computational modeling and a cell cycle-reporting axolotl reveal how spinal cord regeneration can be achieved by a signal that propagates 828 μm from the injury site during the first 85 hours post-amputation.
    1. Neuroscience

    Spatiotemporal properties of glutamate input support direction selectivity in the dendrites of retinal starburst amacrine cells

    Prerna Srivastava, Geoff de Rosenroll ... Gautam Bhagwan Awatramani
    Two-photon glutamate imaging reveals that 'sustained' and 'transient' input are systematically arranged along single starburst dendrites, supporting the 'space-time' wiring model for direction selectivity.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing

    Jesse R Holt, Wei-Zheng Zeng ... Medha M Pathak
    Piezo1 activity within keratinocytes slows healing of wounded skin via dynamic channel enrichment at regions of the wound edge, causing localized retraction and thus hindering keratinocyte migration during wound healing.
    1. Physics of Living Systems

    Cell-sized confinement controls generation and stability of a protein wave for spatiotemporal regulation in cells

    Shunshi Kohyama, Natsuhiko Yoshinaga ... Nobuhide Doi
    A cell-sized fully confined space significantly controls the emergence and stability of a protein wave, resulting in intracellular spatiotemporal regulation driven by a reaction-diffusion mechanism.
    1. Cell Biology
    2. Developmental Biology

    GIV/Girdin, a non-receptor modulator for Gαi/s, regulates spatiotemporal signaling during sperm capacitation and is required for male fertility

    Sequoyah Reynoso, Vanessa Castillo ... Pradipta Ghosh
    Spermatozoa require GIV for specialized compartmentalized signaling to support efficient capacitation while inhibiting premature acrosome reaction.
    1. Evolutionary Biology

    Modeling the spatiotemporal spread of beneficial alleles using ancient genomes

    Rasa A Muktupavela, Martin Petr ... Fernando Racimo
    A new method for inferring the spatiotemporal dynamics governing the spread of an advantageous mutation using ancient DNA.

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