A cell-sized fully confined space significantly controls the emergence and stability of a protein wave, resulting in intracellular spatiotemporal regulation driven by a reaction-diffusion mechanism.

An individual extracellular signal regulates multiple cellular actions through differences in the temporal dynamics of spatially distinct populations of the central signaling enzyme, extracellular-signal regulated kinase.

Autophagic flux assays in the nematode Caenorhabditis elegans suggest that autophagy decreases during normal aging, whereas long-lived daf-2 and glp-1 mutants maintain autophagic capacity in distinct spatiotemporal-specific manners to extend lifespan.

Self-activating Aurora B kinase, opposed by an inhibitory phosphatase, forms spatial phosphorylation patterns during cell division.

Restoration of molecular and morphological symmetry and mechanical integrity following epithelial fusion relies on adaptive changes that are mediated by cytoskeletal tension and Bazooka dependent modulation of fusing interface geometry.

Light-sensitive allosteric switch module, a broadly applicable protein engineering method, is used for the regulation of protein activity with tight temporal control and spatial precision.

Cell imaging and electrophysiology in the mouse hippocampus reveal a crucial role for the spatiotemporal regulation of mitochondrial dynamics in PV+ interneurons on cell morphology, network activity, and behavior.

Combining quantitative biological experiment and physical description of actomyosin cortex reveals a contractile instability in the cortex of C. elegans embryo, and its biochemical control in order to robustly drive morphogenetic events.

Through visualization of directly-labeled RhoGTPase both in vitro and in vivo, RhoGDI is found to spatiotemporally regulate RhoGTPase activity through the extraction of active RhoGTPase.

Optogenetic manipulation of BMP signaling indicates that diversity in BMP-dependent gene expression is not well explained by differential responses to BMP, and combinatorial signaling is a major driver of diversity.