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    1. Cell Biology

    Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte

    Huiliang Zhang et al.
    The primary respiratory defect seen in aged cardiomyocytes is an elevated proton leak mediated by ANT1, and this is prevented by treatment with SS-31 (elamipretide).
    1. Neuroscience

    Feeding state functionally reconfigures a sensory circuit to drive thermosensory behavioral plasticity

    Asuka Takeishi et al.
    Starvation modulates thermotaxis behaviors in C. elegans via functional reconfiguration of a sensory network by gut-brain signaling.
    1. Neuroscience

    mTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking

    Nadege Morisot et al.
    In the orbitofrontal cortex, mTORC1, a multiprotein complex centered around the kinase mTOR, contributes to the development and/or maintenance of habitual alcohol seeking.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    E. coli TraR allosterically regulates transcription initiation by altering RNA polymerase conformation

    James Chen et al.
    Cryo-electron microscopy structures, combined with biochemical experiments, show how the E. coli F element-encoded TraR protein regulates transcription initiation by altering RNA polymerase conformation and conformational heterogeneity.
    1. Evolutionary Biology
    2. Plant Biology

    Asymmetrical diversification of the receptor-ligand interaction controlling self-incompatibility in Arabidopsis

    Maxime Chantreau et al.
    In-planta ancestral protein resurrection of the female determinant of self-incompatibility specificity in Arabidopsis halleri demonstrates that two allelic variants currently segregating as distinct receptor-ligand combinations diverged through an asymmetrical process.
    1. Neuroscience

    A primal role for the vestibular sense in the development of coordinated locomotion

    David E Ehrlich, David Schoppik
    Zebrafish use their sense of gravity and their cerebellum to coordinate the fin and body movements that, as they develop, allow them to better maintain balance as they climb.
    1. Neuroscience

    Dopamine neuron ensembles signal the content of sensory prediction errors

    Thomas A Stalnaker et al.
    Dopamine neurons function as an ensemble to signal a multidimensional feature prediction error.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock

    Andrea Brenna et al.
    Cyclin-dependent kinase 5 regulates the circadian clock involving phosphorylation of the PER2 protein.
    1. Neuroscience

    Kv1.1 contributes to a rapid homeostatic plasticity of intrinsic excitability in CA1 pyramidal neurons in vivo

    Peter James Morgan et al.
    Short, theta-bursts of action potential firing decrease the global excitability of CA1 pyramidal neurons, providing an internal mechanism which could regulate their allocation to memory engrams.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Distinct roles for S. cerevisiae H2A copies in recombination and repeat stability, with a role for H2A.1 threonine 126

    Nealia CM House et al.
    Despite differing by only one amino acid in the C-terminal tail, copy 1 of yeast histone 2A has a repair-specific role not shared by copy 2.