A data-driven network model offers an interpretable and physiologically sound description of the whole-brain spontaneous neural activity of zebrafish larvae.

Temporal continuity-induced plasticity in individual neurons of inferior temporal cortex builds neural representations that underlie robust core object recognition behavior.

SINE RNAs are implicated in amyloid beta molecular pathology in hippocampus.

Non-invasive disinhibition of the oculomotor system shows that ongoing preparatory activity in the superior colliculus has movement-generating potential and need not rise to threshold in order to produce a saccade.

A new dynamic mechanistic model explains how the destruction complex negatively regulates Wnt signaling in development and oncogenesis.

The structure-based design established a new approach to control pathway-selective activation of opioid receptors, resulting in new dual MOR/KOR G-protein biased agonist analgesics with attenuated liabilities.

The importance of synchronous Purkinje cell complex spikes for controlling cerebellar output was investigated by simultaneously recording from cerebellar nuclear cells and arrays of Purkinje cells that synapse onto them.

The evolutionarily conserved polarity protein Crumbs links the regulation of cytoskeleton dynamics and cell-cell adhesion with epithelial morphogenesis.

Protein disaggregases employ two mechanically-linked ATPase rings that are under steric control by a wrapped-around coiled-coil belt.

The evidence of subspace computation in the lateral prefrontal cortex provides insights into the neural mechanisms underlying cognitive flexibility and interference between different cognitive processes.