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    1. Neuroscience

    Transformation of spatiotemporal dynamics in the macaque vestibular system from otolith afferents to cortex

    Jean Laurens, Sheng Liu ... Dora E Angelaki
    The spatial and dynamic properties of self-motion signals are acquired at the first stage of otolith signal transformation, which is in the brainstem and cerebellum, and conserved across brainstem, cerebellar and cortical areas.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Dynamics of ribosomes and release factors during translation termination in E. coli

    Sarah Adio, Heena Sharma ... Marina V Rodnina
    Translation termination is a stochastic process that utilizes loosely coupled motions of its players to complete protein synthesis and release the newly synthesized nascent chain toward its cellular destination.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Lateral interactions between protofilaments of the bacterial tubulin homolog FtsZ are essential for cell division

    Fenghui Guan, Jiayu Yu ... Sheng Ye
    Structural and functional approaches unambiguously revealed physiologically relevant lateral interactions between FtsZ protofilaments.
    1. Developmental Biology
    2. Neuroscience

    Synaptic mitochondria regulate hair-cell synapse size and function

    Hiu-tung C Wong, Qiuxiang Zhang ... Katie Kindt
    Mitochondrial calcium influx plays distinct roles in presynapse formation, function and stability in sensory hair cells.
    1. Neuroscience

    Rapid whole brain imaging of neural activity in freely behaving larval zebrafish (Danio rerio)

    Lin Cong, Zeguan Wang ... Quan Wen
    The integration of a novel high spatiotemporal resolution volume imaging technique and a fast 3D tracking system allows capturing whole brain neural activities in a freely behaving larval zebrafish.
    1. Plant Biology

    The tRNA thiolation-mediated translational control is essential for plant immunity

    Xueao Zheng, Hanchen Chen ... Shunping Yan
    The transfer RNA thiolation modification is required for the efficient translation of the master immune regulator NPR1 in plants.
    1. Cell Biology

    Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte

    Huiliang Zhang, Nathan N Alder ... Peter S Rabinovitch
    The primary respiratory defect seen in aged cardiomyocytes is an elevated proton leak mediated by ANT1, and this is prevented by treatment with SS-31 (elamipretide).
    1. Neuroscience

    Bright multicolor labeling of neuronal circuits with fluorescent proteins and chemical tags

    Richi Sakaguchi, Marcus N Leiwe, Takeshi Imai
    A bright and stochastic multicolor labeling method, Tetbow, facilitates millimeters-scale reconstructions of neuronal circuits at a large scale using tissue clearing.
    1. Ecology

    Delayed postglacial colonization of Betula in Iceland and the circum North Atlantic

    David J Harning, Samuel Sacco ... Gifford H Miller
    Following the last deglaciation in the North Atlantic, DNA evidence shows Betulaceae colonization was consistently delayed compared to Salicaceae, which may serve as an analog for modern global warming.
    1. Microbiology and Infectious Disease

    HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137

    Fengwen Zhang, Paul D Bieniasz
    A key target of the HIV-1 Vpr accessory protein is identified, whose depletion causes increased HIV-1gene expression and cell cycle arrest.