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    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism

    Anirban Roy, Meiricris Tomaz da Silva ... Ashok Kumar
    The IRE1/XBP1 signaling in myofibers is essential for robust skeletal muscle regeneration in response to injury.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Axon-specific microtubule regulation drives asymmetric regeneration of sensory neuron axons

    Ana C Costa, Blanca R Murillo ... Monica M Sousa
    Revised
    Reviewed Preprint v2
    Updated
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    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Cell-type diversity and regionalized gene expression in the planarian intestine

    David J Forsthoefel, Nicholas I Cejda ... Phillip A Newmark
    Application of laser-capture microdissection to planarian intestinal tissue provides a new tool for analysis of tissue-specific gene expression in flatworms, and a new resource to advance investigations of gastrointestinal regeneration.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Planarian stem cells sense the identity of the missing pharynx to launch its targeted regeneration

    Tisha E Bohr, Divya A Shiroor, Carolyn E Adler
    Loss of a single organ, the planarian pharynx, triggers immediate proliferation and expansion of stem cells required to replace it.
    1. Developmental Biology

    Klf5 regulates muscle differentiation by directly targeting muscle-specific genes in cooperation with MyoD in mice

    Shinichiro Hayashi, Ichiro Manabe ... Yumiko Oishi
    The regulatory programs governing skeletal muscle regeneration that are controlled by Klf5 in cooperation with MyoD and Mef2 provide a potential avenue for intervention into muscle regeneration through modulation of Klf5.
    1. Stem Cells and Regenerative Medicine
    2. Microbiology and Infectious Disease

    Pathogenic shifts in endogenous microbiota impede tissue regeneration via distinct activation of TAK1/MKK/p38

    Christopher P Arnold, M Shane Merryman ... Alejandro Sánchez Alvarado
    An innate immune system signaling pathway in planarians has a dual role: it enhances apoptosis during bacterial infection, but represses apoptosis during tissue regeneration in the absence of infection.
    1. Developmental Biology

    Arid3a regulates nephric tubule regeneration via evolutionarily conserved regeneration signal-response enhancers

    Nanoka Suzuki, Kodai Hirano ... Haruki Ochi
    Arid3a, a component of H3K9 me3 demethylases, regulates regeneration of the proximal nephric tubule through the evolutionarily conserved regeneration signal-response enhancer.
    1. Evolutionary Biology
    2. Stem Cells and Regenerative Medicine

    A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice

    Michael J Abrams, Fayth Hui Tan ... Lea Goentoro
    Amino acid and sugar supplement induce appendage/limb regeneration in cnidarians, insects, and mammals.
    1. Stem Cells and Regenerative Medicine

    Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair

    Juan Carlos Lopez-Baez, Daniel J Simpson ... E Elizabeth Patton
    Wound-specific notochord sheath cell subpopulations associate with notochord repair and adult vertebrae formation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Neural control of growth and size in the axolotl limb regenerate

    Kaylee M Wells, Kristina Kelley ... Catherine D McCusker
    Signaling from the limb nerves regulates the rate of growth and the overall size of the regenerating limb.