The direct interaction of R-type Ca2+ channel Cav2.3 and GABAB receptor auxiliary subunits in the active zone of medial habenula terminals scales synaptic strength independent of GABAB receptor activation.
Transcriptomic analysis using a novel information-based network entropy approach provides mechanistic insights into the ability of Klotho to successfully ameliorate age-related sarcopenia in old mice, but not oldest-old mice.
Immunohistochemical labeling of antigens deep within mouse brain tissue sections was achieved without the need for lipid permeabilization, thereby preserving tissue ultrastructure and enabling correlative light and electron microscopy studies.
Biological aging processes and age-related diseases demonstrate sexual dimorphism where complex interactions between underlying aging mechanisms and sex chromosomes and hormones are seen in humans and animals.
Actively regulated immune memory differentiation, with a preference for cross-reactive receptors with moderate affinity against pathogens as opposed to high-affinity receptors, confers a long-term benefit to the host.
Developing T cells whose TCRs have relatively low reactivity experience very brief TCR signaling events, experience delayed positive selection, and retaina preselection gene expression signature as they mature.