11 results found
    1. Neuroscience

    An hourglass circuit motif transforms a motor program via subcellularly localized muscle calcium signaling and contraction

    Steven R Sando, Nikhil Bhatla ... H Robert Horvitz
    By driving the localized contraction of subcellular muscle regions, a single motor neuron reverses the flow of material in the Caenorhabditis elegans pharynx, a neuromuscular pump, converting feeding into spitting.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Delivery of a Jagged1-PEG-MAL hydrogel with pediatric human bone cells regenerates critically sized craniofacial bone defects

    Archana Kamalakar, Brendan Tobin ... Steven L Goudy
    Innovative JAGGED1-based therapies show promise for pediatric craniofacial bone loss, potentially overcoming limitations of current treatments with more effective and accessible solutions.
    1. Neuroscience

    The integrated brain network that controls respiration

    Friedrich Krohn, Manuele Novello ... Laurens WJ Bosman
    The primary rhythm generators controlling respiration are integrated in a much larger network of brain regions, including areas not typically considered to be respiratory control centers, and that allow respiration to be adapted to all forms of ongoing behavior.
    1. Neuroscience

    The breath shape controls intonation of mouse vocalizations

    Alastair MacDonald, Alina Hebling ... Kevin Yackle
    The breathing motor program is re-engaged to control the fluctuations in vocal pitch during a sound.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Fundamental constraints in synchronous muscle limit superfast motor control in vertebrates

    Andrew F Mead, Nerea Osinalde ... Coen PH Elemans
    Vertebrate superfast muscles employ similar excitation–contraction strategies but distinct myosin heavy chain genes to allow superfast performance, revealing a maximum speed that cannot be overcome without sacrificing neural control.
    1. Developmental Biology

    Cilia-mediated Hedgehog signaling controls form and function in the mammalian larynx

    Jacqueline M Tabler, Maggie M Rigney ... John B Wallingford
    Genetic studies in mice reveal the molecular and embryological mechanisms of vocal fold development and function, thereby informing our understanding of vocal communication and congenital voice defects.
    1. Neuroscience

    Task-dependent coarticulation of movement sequences

    Hari Teja Kalidindi, Frederic Crevecoeur
    Long-latency reflexes flexibly encode future goals during sequential reaching movements, reflecting the parallel and task-dependent processing of a sequence of goals in circuits that mediate fast feedback control.
    1. Physics of Living Systems

    Speech Biomechanics: Shaping new sounds

    Timothy D Griffiths, Kai Alter, Barbara Shinn-Cunningham
    MRI experiments have revealed how throat singers from Tuva produce their characteristic sound.
    Version of Record
    Insight
    1. Physics of Living Systems

    Overtone focusing in biphonic tuvan throat singing

    Christopher Bergevin, Chandan Narayan ... Brad Story
    In light of the mysteries underlying the biphonic nature of Tuvan throat song, information from multiple modalities is combined to explain how this remarkable phenomenon is achieved biomechanically.
    1. Neuroscience

    Vocal and locomotor coordination develops in association with the autonomic nervous system

    Morgan L Gustison, Jeremy I Borjon ... Asif A Ghazanfar
    Marmoset monkeys develop their vocal behavior prior to their postural and locomotor skills, but the coordination of these two motor systems emerges gradually via changes in arousal level.

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