2,390 results found
  1. Rebooting reproducibility: From re-execution to replication

    Critical questions for building and employing more useful tools for reproducible research.
  2. October 2015

    Episode 24: October 2015

    In this episode we hear about Parkinson's Disease, depression, chickenpox, bats, beetles, and how small prey can escape larger predators.
  3. February 2016

    Episode 27: February 2016

    In this episode we hear about midnight snacking, X-ray imaging of fossils, hummingbirds, monkeys gambling and axolotls regenerating.
  4. postits

    Innovation Sprint 2020: Design, test, learn, repeat

    We reflected on the first two iterations of the eLife Innovation Sprint, and are ready to share our plans for the next.
    1. Neuroscience

    Rapid computations of spectrotemporal prediction error support perception of degraded speech

    Ediz Sohoglu, Matthew H Davis
    Analysis of speech acoustics and human brain activity reveals the neural computations by which listeners combine speech input with prior expectations.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Arrayed CRISPRi and quantitative imaging describe the morphotypic landscape of essential mycobacterial genes

    Timothy J de Wet et al.
    A high-throughput functional genomics approach combining inducible CRISPR-interference and quantitative imaging yields an atlas of 'phenoprints' to guide gene function assignments, identify metabolic pathway-specific morphotypes, and inform antibiotic mechanism-of-action studies.
    1. Cell Biology

    SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism

    Ashutosh Kumar et al.
    LRRC8A is an essential component of a mechanoresponsive ion channel signaling complex that tunes skeletal muscle differentiation, muscle cell size, function and metabolic pathways to regulate adiposity and systemic glycemia.
    1. Computational and Systems Biology
    2. Neuroscience

    Tuning movement for sensing in an uncertain world

    Chen Chen et al.
    Animals work in a world full of surprises, where using energy to position sensors proportional to the location's expected information avoids the pitfalls of positioning them at the information maxima.
    1. Microbiology and Infectious Disease

    A single mutation in Crimean-Congo hemorrhagic fever virus discovered in ticks impairs infectivity in human cells

    Brian L Hua et al.
    Tick-derived sequence variation in the fusion glycoprotein of Crimean-Congo hemorrhagic fever virus (CCHFV) drastically impairs infection of mammalian cells, suggesting that certain CCHFV strains undergo purifying selection in mammalian hosts.
    1. Neuroscience

    Mother brain is wired for social moments

    Ortal Shimon-Raz et al.
    Mother brain shows special sensitivity to social moments of mother-infant synchrony, compared to other caregiving experiences, through enhanced activation across the caregiving network, response to oxytocin administration, and temporal consistency.

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