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    1. Neuroscience

    An Anatomical and Physiological Basis for Flexible Coincidence Detection in the Auditory System

    Lauren J Kreeger, Suraj Honnuraiah ... Lisa V Goodrich
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses

    Nicolas Michalski, Juan D Goutman ... Christine Petit
    Targeted mutations in a Ca2+-binding site of otoferlin, a transmembrane protein of synaptic vesicles defective in a recessive form of deafness, reveal its Ca2+ sensor role both for vesicle fusion and vesicle pool replenishment.
    1. Neuroscience

    Sushi domain-containing protein 4 controls synaptic plasticity and motor learning

    Inés González-Calvo, Keerthana Iyer ... Fekrije Selimi
    SUSD4 loss-of-function induces misregulation of GLUA2 degradation and of synaptic plasticity suggesting a mechanism for its potential contribution to neurodevelopmental disorders.
    1. Neuroscience

    Persistent neural activity in auditory cortex is related to auditory working memory in humans and nonhuman primates

    Ying Huang, Artur Matysiak ... Michael Brosch
    The auditory cortex temporarily stores task-relevant information by persistently changed neuronal activity of single neurons and of neuronal populations.
    1. Neuroscience

    Episodic long-term memory formation during slow-wave sleep

    Flavio J Schmidig, Simon Ruch, Katharina Henke
    Sleep-encoded vocabulary influences awake decision-making 36 hr later, particularly when targeting the vocabulary to slow-wave troughs, which suggests that unconscious episodic memory formation during deep sleep is possible.
    1. Cell Biology

    Organization, functions, and mechanisms of the BBSome in development, ciliopathies, and beyond

    Xiaoyu Tian, Huijie Zhao, Jun Zhou
    Theoretical analysis of the current literature reveals the structural assembly, transport regulation, and molecular functions of the BBSome, emphasizing its roles in cilium-related processes.
    1. Neuroscience

    Different types of theta rhythmicity are induced by social and fearful stimuli in a network associated with social memory

    Alex Tendler, Shlomo Wagner
    Variations in the frequency of theta brain waves enable a single network of brain regions to generate appropriate responses to stimuli with different kinds of emotional value.
    1. Neuroscience

    Improving the accuracy of single-trial fMRI response estimates using GLMsingle

    Jacob S Prince, Ian Charest ... Kendrick N Kay
    GLMsingle is a publicly available toolbox for analyzing fMRI time-series data that leverages data-driven optimization techniques to improve the accuracy of single-trial BOLD response estimates.
    1. Neuroscience

    Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain

    Julio D Perez, Nimrod D Rubinstein ... Catherine Dulac
    A subset of genes in the mouse brain show dynamically regulated and unequal expression of maternally and paternally derived variants, with implications for brain development and function.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    A common bacterial metabolite elicits prion-based bypass of glucose repression

    David M Garcia, David Dietrich ... Daniel F Jarosz
    Activity-guided fractionation identifies the first bacterial metabolite that potently induces a prion in nature.