4,488 results found
    1. Neuroscience

    Impaired speed encoding and grid cell periodicity in a mouse model of tauopathy

    Thomas Ridler, Jonathan Witton ... Jonathan T Brown
    Dementia-related tau pathology reduces speed encoding in the medial entorhinal cortex and is associated with reduced grid cell function, whilst head direction tuning remains intact.
    1. Physics of Living Systems

    Heterogeneous T cell motility behaviors emerge from a coupling between speed and turning in vivo

    Elizabeth R Jerison, Stephen R Quake
    Motile interstitial T cells in live zebrafish access a broad range of length-scales due to long-lived cell-intrinsic variation in speed, and a coupling between speed and directional persistence.
    1. Computational and Systems Biology

    Hidden long-range memories of growth and cycle speed correlate cell cycles in lineage trees

    Erika E Kuchen, Nils B Becker ... Thomas Höfer
    The combination of statistical inference and perturbation experiments reveals that trans-generational inheritance of cell size and cell-cycle speed, coupled through a minimum-size checkpoint, shapes paradoxical cell-cycle correlations in lineage trees.
    1. Cell Biology
    2. Neuroscience

    Speed and segmentation control mechanisms characterized in rhythmically-active circuits created from spinal neurons produced from genetically-tagged embryonic stem cells

    Matthew J Sternfeld, Christopher A Hinckley ... Samuel L Pfaff
    Stem cell derived ventral-spinal cord excitatory neurons self-assemble into a rhythmically bursting neural network whose speed and intercellular coordination are both instructively modulated by cell-type specific interactions with inhibitory neurons.
    1. Neuroscience

    Effects of visual inputs on neural dynamics for coding of location and running speed in medial entorhinal cortex

    Holger Dannenberg, Hallie Lazaro ... Michael E Hasselmo
    Spatial accuracy of grid cell firing correlates with the slope of the local field potential theta frequency vs. running speed relationship and integrates velocity signals over past time.
    1. Developmental Biology

    Carm1-arginine methylation of the transcription factor C/EBPα regulates transdifferentiation velocity

    Guillem Torcal Garcia, Elisabeth Kowenz-Leutz ... Thomas Graf
    A mutation in the lineage-determining regulator C/EBPα that increases the factor’s affinity for its partner PU.1 dramatically accelerates the velocity of B cell to macrophage transdifferentiation.
    1. Neuroscience

    Visual landmarks sharpen grid cell metric and confer context specificity to neurons of the medial entorhinal cortex

    José Antonio Pérez-Escobar, Olga Kornienko ... Kevin Allen
    The firing rate of MEC neurons conveys information about visual landmarks.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity

    Breane G Budaitis, Shashank Jariwala ... Kristen J Verhey
    Force generation by kinesin motor proteins requires formation of both a 2-stranded cover-neck bundle and an asparagine-based latch for transport of membrane-bound cargoes in cells.
    1. Neuroscience

    Long-term transverse imaging of the hippocampus with glass microperiscopes

    William T Redman, Nora S Wolcott ... Michael J Goard
    Two-photon imaging through glass microperiscopes allows imaging of the transverse plane of the hippocampus, including all major subfields, in awake behaving mice.
    1. Computational and Systems Biology

    Distributing tasks via multiple input pathways increases cellular survival in stress

    Alejandro A Granados, Matthew M Crane ... Peter S Swain
    Single-cell experiments and mathematical modelling show that cellular signalling networks are vulnerable to trade-offs in speed versus accuracy, but that these vulnerabilities can be overcome by distributing the two tasks to different, although interacting, subnetworks.

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