460 results found
    1. Computational and Systems Biology

    Tuning the speed-accuracy trade-off to maximize reward rate in multisensory decision-making

    Jan Drugowitsch et al.
    Building on previous work (Drugowitsch et al., 2014), it is shown that decision-makers adjust their speed-accuracy trade-off flexibly from one moment to the next, based on evidence available from multiple sensory modalities, in order to nearly maximize their reward rate.
    1. Computational and Systems Biology

    Distributing tasks via multiple input pathways increases cellular survival in stress

    Alejandro A Granados et al.
    Single-cell experiments and mathematical modelling show that cellular signalling networks are vulnerable to trade-offs in speed versus accuracy, but that these vulnerabilities can be overcome by distributing the two tasks to different, although interacting, subnetworks.
    1. Neuroscience

    A neural mechanism of speed-accuracy tradeoff in macaque area LIP

    Timothy Hanks et al.
    To establish a trade-off between the speed and accuracy of a decision, neurons in lateral intraparietal cortex combine evidence bearing on the decision with a signal that incorporates the cost of time into the decision-making process.
    1. Cell Biology
    2. Computational and Systems Biology

    Science Forum: The Human Cell Atlas

    Aviv Regev et al.
    Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
    1. Ecology
    2. Human Biology and Medicine

    Point of View: A transatlantic perspective on 20 emerging issues in biological engineering

    Bonnie C Wintle et al.
    Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.
  1. Point of View: How should novelty be valued in science?

    Barak A Cohen
    An over-emphasis on novelty is having detrimental effects on science.
    1. Cell Biology
    2. Computational and Systems Biology

    Principles of cellular resource allocation revealed by condition-dependent proteome profiling

    Eyal Metzl-Raz et al.
    Steadily growing cells prepare for conditions that demand increased translation by producing excess ribosomes, at the expense of lower steady-state growth rate.
    1. Neuroscience

    A quantitative theory of gamma synchronization in macaque V1

    Eric Lowet et al.
    Gamma-band synchronization behavior in area V1 was predicted by weakly coupled oscillator principles.
    1. Computational and Systems Biology
    2. Neuroscience

    Microsaccadic sampling of moving image information provides Drosophila hyperacute vision

    Mikko Juusola et al.
    New experiments and theory reveal how the ability to see image details depends upon photoreceptor function and eye movements, and how fruit flies (Drosophila) see spatial details beyond the optical limit of their compound eyes.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Temporal profiling of redox-dependent heterogeneity in single cells

    Meytal Radzinski et al.
    Analysis of aging yeast cells using the in-vivo roGFP2-based probe reveals redox-dependent heterogeneity, reflected in a bi-modal distribution of the oxidation status, differential growth and replication, as well as distinct proteomic and transcriptomic profiles.

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