352 results found
    1. Cell Biology
    2. Physics of Living Systems

    Flagellar energetics from high-resolution imaging of beating patterns in tethered mouse sperm

    Ashwin Nandagiri et al.
    Calculations of flagellar energetics from beating patterns in sperm reveal that internal dissipation by dynein motors and other passive structures within the flagellum significantly exceeds external hydrodynamic dissipation.
    1. Developmental Biology

    Essential role for SUN5 in anchoring sperm head to the tail

    Yongliang Shang et al.
    SUN5 is essential for the tight junction between sperm head and the head-tail coupling apparatus, and is the main cause of human acephalic spermatozoa syndrome.
    1. Cell Biology
    2. Developmental Biology

    TMEM95 is a sperm membrane protein essential for mammalian fertilization

    Ismael Lamas-Toranzo et al.
    TMEM95, a protein localized to the sperm acrosome cap, is essential for fertilization.
    1. Cell Biology
    2. Genetics and Genomics

    A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster

    Maulik R Patel et al.
    A 'male-harming' mtDNA mutation has been identified in Drosophila and impairs male fertility without impairing other male or female functions.
    1. Cell Biology
    2. Developmental Biology

    Philosophy of Biology: The analysis of living systems can generate both knowledge and illusions

    Antony M Jose
    By thinking about experimental techniques in terms of six broad approaches – perturbation, visualization, substitution, characterization, reconstitution, and simulation – researchers may be able to generate more reliable inferences.
    1. Neuroscience

    Connectomics: Think small

    Luis A Bezares-Calderón, Gáspár Jékely
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    1. Developmental Biology

    Contraception: Stopping sperm in their tracks

    Luke L McGoldrick, Jean-Ju Chung
    An automated high-throughput platform can screen for molecules that change the motility of sperm cells and their ability to fertilize.
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    1. Cell Biology

    Cell Division: How centrioles acquire the ability to reproduce

    Midori Ohta et al.
    A protein called SAS-7 is required for daughter centrioles to become mothers in C. elegans.
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    1. Cell Biology
    2. Microbiology and Infectious Disease

    Cryo electron tomography with volta phase plate reveals novel structural foundations of the 96-nm axonemal repeat in the pathogen Trypanosoma brucei

    Simon Imhof et al.
    Cryo electron tomography provides the first high-resolution 3D axoneme structure from any pathogenic organism, revealing novel structures that support the unique motility of these pathogens through host tissues.

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