201 results found
    1. Developmental Biology
    2. Genetics and Genomics

    Nuclear receptor Ftz-f1 promotes follicle maturation and ovulation partly via bHLH/PAS transcription factor Sim

    Elizabeth M Knapp et al.
    Genetic analyses illustrate the novel requirement of Ftz-f1 and Sim in adult Drosophila ovaries for regulating follicle cell differentiation and ovulation that is likely conserved in mammals.
    1. Developmental Biology
    2. Genetics and Genomics

    Zygotic gene activation in the chicken occurs in two waves, the first involving only maternally derived genes

    Young Sun Hwang et al.
    In Aves, the first wave of transcription is derived exclusively from the maternal genome.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Vilya, a component of the recombination nodule, is required for meiotic double-strand break formation in Drosophila

    Cathleen M Lake et al.
    The Zip3-like protein Vilya links the initiation of meiotic recombination with crossover formation.
    1. Cell Biology

    GnT1IP-L specifically inhibits MGAT1 in the Golgi via its luminal domain

    Hung-Hsiang Huang et al.
    GnT1IP-L is a membrane bound glycoprotein that interacts with MGAT1 in the Golgi, but not in the endoplasmic reticulum, to regulate complex N-glycan synthesis.
    1. Developmental Biology
    2. Genetics and Genomics

    In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse

    Marco Morselli et al.
    DNA methylation deposition is dependent on the presence of H3K4me3 and H3K36me3 histone marks.
    1. Immunology and Inflammation

    IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate

    Mark Noviski et al.
    Self-reactive B cells downregulate the IgM but not the IgD B cell receptor, and this serves as a critical tolerance mechanism because IgD is less sensitive to bona fide endogenous antigens than IgM.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Multiplex CRISPR/Cas screen in regenerating haploid limbs of chimeric Axolotls

    Lucas D Sanor et al.
    A novel CRISPR-based genetic screen of candidate regeneration genes in haploid axolotl limbs reveals two genes required for proper regeneration.
    1. Chromosomes and Gene Expression

    Asymmetry between the two acidic patches dictates the direction of nucleosome sliding by the ISWI chromatin remodeler

    Robert F Levendosky, Gregory D Bowman
    Unlike Chd1, ISWI remodelers preferentially shift asymmetric nucleosomes toward the side possessing a wild type acidic patch, regardless of DNA lengths flanking the nucleosome.
    1. Neuroscience

    Oxytocin signaling in the medial amygdala is required for sex discrimination of social cues

    Shenqin Yao et al.
    Oxytocin signaling plays a critical role in a molecularly defined neuronal population of the Medial Amygdala to modulate the behavioral and physiological responses of male mice to females on a moment-to-moment basis.
    1. Genetics and Genomics

    Quiescence unveils a novel mutational force in fission yeast

    Serge Gangloff et al.
    The quiescence-driven mutational landscape reveals replication-independent mutagenesis as a novel evolutionary force.

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