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    1. Developmental Biology

    Partial rejuvenation of the spermatogonial stem cell niche after gender-affirming hormone therapy in trans women

    Emily Delgouffe, Samuel Madureira Silva ... Ellen Goossens
    Gender-affirming hormone therapy in trans women leads to a loss of mature characteristics in the spermatogonial stem cell niche, causes spermatogenic arrest, and triggers fibrotic processes.
    1. Cell Biology

    Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis

    Zewei Zhao, Longyun Hu ... Zhonghan Yang
    ADGRA3 signaling promotes adipose thermogenesis via Gs-PKA-CREB, suggesting hesperetin and ADGRA3 overexpression as obesity therapies.
    1. Neuroscience

    The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion

    Lian Hollander-Cohen, Omer Cohen ... Berta Levavi-Sivan
    Genetic loss-of-function approaches and functional calcium imaging reveal cholecystokinin as the primary regulator of follicle-stimulating hormone in zebrafish, redefining our understanding of gonadotropin regulation in vertebrates.
    1. Developmental Biology

    CCDC113 stabilizes sperm axoneme and head-tail coupling apparatus to ensure male fertility

    Bingbing Wu, Chenghong Long ... Chao Liu
    CCDC113 is a key structural hub for sperm axoneme and head-tail coupling apparatus (HTCA) stability, with defects leading to male infertility through disruption of sperm flagellar and HTCA integrity.
    1. Developmental Biology
    2. Genetics and Genomics

    ARID1A governs the silencing of sex-linked transcription during male meiosis in the mouse

    Debashish U Menon, Prabuddha Chakraborty ... Terry Magnuson
    ARID1A is implicated in BAF-A-governed meiotic sex chromosome gene regulation and sex-linked chromatin dynamics in DNA repair.
    1. Genetics and Genomics

    DNAH3 deficiency causes flagellar inner dynein arm loss and male infertility in humans and mice

    Xiang Wang, Gan Shen ... Ying Shen
    DNAH3 is a novel pathogenic gene of male infertility and plays essential role in flagellar IDA assembly in humans and mice.
    1. Developmental Biology
    2. Genetics and Genomics

    Diverse somatic Transformer and sex chromosome karyotype pathways regulate gene expression in Drosophila gonad development

    Sharvani Mahadevaraju, Soumitra Pal ... Brian Oliver
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Chromosomes and Gene Expression

    Nuclear Argonaute protein NRDE-3 switches small RNA binding partners during embryogenesis coincident with the formation of SIMR granules

    Shihui Chen, Carolyn M Phillips
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Evolutionary Biology
    2. Medicine

    The conserved genetic program of male germ cells uncovers ancient regulators of human spermatogenesis

    Rion Brattig-Correia, Joana M Almeida ... Paulo Navarro-Costa
    An interdisciplinary research platform reveals that the transcriptional identity of metazoan male germ cells is built around a small network of deeply conserved gene interactions with an overarching functional impact.
    1. Developmental Biology

    Mechanistic target of rapamycin (mTOR) pathway in Sertoli cells regulates age-dependent changes in sperm DNA methylation

    Saira Amir, Olatunbosun Arowolo ... Alexander Suvorov
    For the first time, a molecular mechanism is identified, for experimental acceleration and deceleration (rejuvenation) of sperm epigenetic aging.
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