The mammalian Y chromosome has become specialised for male fertility, but exact functions of individual Y genes remain poorly understood, a knowledge gap that new approaches can bridge.
The mouse gene Ythdc2 exemplifies an evolutionarily ancient family of crucial regulators of the transition from germline stem cell divisions to meiosis.
Madhav Jagannathan, Ryan Cummings, Yukiko M Yamashita
Satellite DNA mediates clustering of multiple chromosomes via formation of chromocenter to encapsulate the full complement of the genome into a single nucleus.
In vitro reprogramming of human fibroblasts to Sertoli-like cells with immunosuppressive properties provides platforms for basic research and clinical application.
Steven A Cincotta, Nainoa Richardson ... Diana J Laird
Although developing oocytes and sperm of mice both harbor the glucocorticoid receptor, fetal oocytes are resistant to differing levels of gluocorcorticoid stress hormones, while spermatogonia alter RNA splicing.
