70 results found
    1. Cell Biology
    2. Developmental Biology

    GIV/Girdin, a non-receptor modulator for Gαi/s, regulates spatiotemporal signaling during sperm capacitation and is required for male fertility

    Sequoyah Reynoso et al.
    Spermatozoa require GIV for specialized compartmentalized signaling to support efficient capacitation while inhibiting premature acrosome reaction.
    1. Developmental Biology

    A phenotypic screening platform utilising human spermatozoa identifies compounds with contraceptive activity

    Franz S Gruber et al.
    A high-throughput phenotypic human sperm screening platform was developed which allows for major drug discovery programmes for male contraception.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Slo1 is the principal potassium channel of human spermatozoa

    Nadja Mannowetz et al.
    Potassium ions enter and leave human sperm cells via a calcium-dependent ion channel that is also pH-independent.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    3D in situ imaging of the female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice

    Lukas Ded et al.
    Fertilizing mouse spermatozoa, characterized by intact CatSper channels, lack of protein tyrosine phosphorylation, and reacted acrosomes, in the female reproductive tract provide molecular insight into sperm selection for successful fertilization.
    1. Developmental Biology

    Essential role for SUN5 in anchoring sperm head to the tail

    Yongliang Shang et al.
    SUN5 is essential for the tight junction between sperm head and the head-tail coupling apparatus, and is the main cause of human acephalic spermatozoa syndrome.
    1. Physics of Living Systems

    Sperm chemotaxis is driven by the slope of the chemoattractant concentration field

    Héctor Vicente Ramírez-Gómez et al.
    The slope of the chemoattractant concentration gradient is a driving force for sperm chemotaxis, by coordinating the entrainment of information flow between sensing, signaling and motility.
    1. Developmental Biology

    Evolutionarily conserved sperm factors, DCST1 and DCST2, are required for gamete fusion

    Naokazu Inoue et al.
    Mammalian fertilization is accomplished through integrating various molecular pathways that include evolutionarily conserved factors, DCST1 and DCST2.
    1. Structural Biology and Molecular Biophysics

    Semen amyloids participate in spermatozoa selection and clearance

    Nadia R Roan et al.
    Ex vivo characterization of the interaction of human sperm with semen factors reveals that semen amyloids, previously discovered due to their ability to enhance HIV infection, serve a physiological function by promoting disposal of the defective sperm.
    1. Developmental Biology

    Paternal multigenerational exposure to an obesogenic diet drives epigenetic predisposition to metabolic diseases in mice

    Georges Raad et al.
    Predisposition to obesity-associated diseases is dependent on the ancestors' diet.
    1. Physics of Living Systems

    Rheotaxis facilitates upstream navigation of mammalian sperm cells

    Vasily Kantsler et al.
    Mammalian sperm subject to shear flow swim in upstream spirals along the walls bounding such flows, thereby demonstrating a robust mechanism for upstream navigation to the ovum.

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