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An ensemble of conserved G2-quadruplex structures in the untranslated regions of messenger RNAs from genes in the polyamine bioysynthesis pathway sense polyamine levels and regulate polyamine synthesis in cells.

A decrease of the type 2 myotonic dystrophy gene product CNBP causes an impairment of polyamine metabolism and locomotor dysfunction that can be reverted with polyamine supplementation.

Two novel mutations in the GRIN2B gene reduce glutamate affinity by >1000-fold, reduce the receptors proton-sensitivity, and exert a dominant-negative effect over receptors in neurons.

Structural analysis of translating human mitoribosome illustrates elemental steps of translation in mitochondria.

Behavioral and in vivo imaging analysis in the fly suggests that mating-related sensory experience regulates female odor perception and expression of choice behavior through a dopamine-gated learning circuit.

Cellular genetics highlights differences in protein catabolism in general, and the COP9 signalosome in particular, as one major source of human cellular circadian variation.

Multiple RNA-seq approaches globally mapped RNA 3´ ends resulting in the discovery of numerous and diverse RNA regulators.

CUT&RUN (Cleavage Under Targets & Release Using Nuclease) profiles antibody-targeted DNA-binding proteins in situ with high resolution and low background, providing a simple, robust and scalable alternative to chromatin immunoprecipitation.

Genome-wide measurements on mouse liver cells show that transcription, and a particular key transcription factor, have a smaller than expected influence on the mouse circadian system.

Transcriptomes of cells in the Drosophila visual system combined with anatomy and other information reveal new functional insight into the visual circuit.