123 results found
    1. Developmental Biology

    Deficient spermiogenesis in mice lacking Rlim

    Feng Wang et al.
    Genetic analyses in mice identifies Rlim in the spermatogenic cell lineage as a regulator of cytoplasmic reduction during spermiogenesis.
    1. Cell Biology
    2. Developmental Biology

    HIPK4 is essential for murine spermiogenesis

    J Aaron Crapster et al.
    HIPK4 is a male germ cell-enriched kinase that regulates cytoskeletal rearrangements in spermatids during spermiogenesis and is required for male fertility in mice.
    1. Cell Biology

    GnT1IP-L specifically inhibits MGAT1 in the Golgi via its luminal domain

    Hung-Hsiang Huang et al.
    GnT1IP-L is a membrane bound glycoprotein that interacts with MGAT1 in the Golgi, but not in the endoplasmic reticulum, to regulate complex N-glycan synthesis.
    1. Cell Biology
    2. Developmental Biology

    Mitochondrial fusion is required for spermatogonial differentiation and meiosis

    Grigor Varuzhanyan et al.
    Mitochondrial fusion enables a metabolic transition during spermatogenesis.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Mitotic fidelity requires transgenerational action of a testis-restricted HP1

    Mia T Levine et al.
    Analysis of a spermiogenesis protein reveals a new chromatin requirement for synchrony between maternal DNA packaged in the egg and sperm-packaged paternal DNA in the first embryonic mitosis in Drosophila melanogaster.
    1. Developmental Biology

    The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline

    Alexis S Bailey et al.
    Post-transcriptional control by YTHDC2 is required to turn off the mitotic proliferation program and facilitate proper expression of the meiotic program to allow a clean cell fate transition in the germline stem cell lineage.
    1. Chromosomes and Gene Expression

    An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning

    Ingrid Ehrmann et al.
    Cell division by meiosis during sperm production depends on expression of an RNA-binding protein that prevents abnormal RNA-processing pathways.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Testis single-cell RNA-seq reveals the dynamics of de novo gene transcription and germline mutational bias in Drosophila

    Evan Witt et al.
    Single-cell RNA-sequencing and germline substitutions provide novel insights into how testis is a hotspot for evolutionary innovation of genes, expression, and mutation at the single-cell level.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    RNA from a simple-tandem repeat is required for sperm maturation and male fertility in Drosophila melanogaster

    Wilbur Kyle Mills et al.
    Sperm production and male fertility in Drosophila melanogaster depend on transcripts generated from the AAGAG(n) repeated satellite DNA within primary spermatocytes.
    1. Chromosomes and Gene Expression

    Successful transmission and transcriptional deployment of a human chromosome via mouse male meiosis

    Christina Ernst et al.
    Transmission of an entire human chromosome through the mouse male germline reveals an unexpectedly high tolerance of aneuploidy during male meiosis and results in accurate transcriptional deployment despite massive epigenetic remodeling during spermatogenesis.
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