73 results found
    1. Cell Biology

    Sphingomyelin metabolism controls the shape and function of the Golgi cisternae

    Felix Campelo et al.
    Association of curvature generating proteins to the Golgi membranes by sphingomyelin metabolism essentially controls the flatness of a Golgi cisterna that is necessary for efficient sorting and export.
    1. Biochemistry and Chemical Biology

    Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides

    Matthijs Kol et al.
    Photoswitchable ceramides containing an azobenzene photoswitch behave as light-controllable substrates for both sphingomyelin synthase and glucosylceramide synthase.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B

    Wei Fan et al.
    SIRT1, a cellular metabolic sensor, transcriptionally promotes sphingomyelin degradation in embryonic stem cells, which in turn modulates their membrane fluidity and neural differentiation.
    1. Cell Biology
    2. Developmental Biology

    Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

    Maia Kinnebrew et al.
    The patched hedgehog receptor inhibits the transmembrane transducer smoothened by reducing the accessibility of cholesterol locally at the membrane of the primary cilium.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Lipid accumulation controls the balance between surface connection and scission of caveolae

    Madlen Hubert et al.
    Caveolae sense the membrane lipid composition, which influences their dynamic behavior at the cell surface.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis

    Akash Das et al.
    Precise control of cellular cholesterol levels is achieved by organization of cholesterol into three distinct pools in the plasma membrane.
    1. Medicine

    Underlying dyslipidemia postpartum in women with a recent GDM pregnancy who develop type 2 diabetes

    Mi Lai et al.
    Lipid dysmetabolism occurs at postpartum in women who progress from GDM to type 2 diabetes, and specific lipids could predict the progression.
    1. Cell Biology

    Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases

    King Faisal Yambire et al.
    Transcription factors KLF2 and ETV1 repress the transcriptional program of mitochondrial biogenesis, resulting in impaired mitochondrial function in lysosomal storage diseases.
    1. Plant Biology

    Phosphatidylcholines from Pieris brassicae eggs activate an immune response in Arabidopsis

    Elia Stahl et al.
    Plants detect the presence of phospholipids in eggs from a herbivorous insect and trigger innate immunity.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice

    Benjamin A Clarke et al.
    The ORMDL proteins function to restrain the de novo sphingolipid biosynthetic pathway during myelination, when there is a high demand for sphingolipids to prevent excessive accumulation of metabolic intermediates.

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