2,499 results found
    1. Cell Biology
    2. Developmental Biology

    Notochord vacuoles absorb compressive bone growth during zebrafish spine formation

    Jennifer Bagwell et al.
    Live imaging and genetic analyses revealed that notochord vacuoles play a critical role in spine morphogenesis by absorbing vertebral bone growth, thus implicating notochord mechanics in congenital scoliosis.
    1. Neuroscience

    SpikeForest, reproducible web-facing ground-truth validation of automated neural spike sorters

    Jeremy Magland et al.
    Ten popular spike sorting codes are reproducibly benchmarked for accuracy on electrophysiology datasets from eleven laboratories with interactive web-based exploration of thousands of ground-truth units.
    1. Neuroscience

    Inference of nonlinear receptive field subunits with spike-triggered clustering

    Nishal P Shah et al.
    Nonlinear receptive field subunits in retinal ganglion cells are isolated and characterized by clustering spike-triggered stimuli, and validated on population responses to naturalistic and novel closed loop stimuli.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types

    Zharko Daniloski et al.
    A pervasive mutation in the Spike protein of the coronavirus that causes COVID-19 results in virions that are up to eightfold more infectious.
    1. Neuroscience

    A spike sorting toolbox for up to thousands of electrodes validated with ground truth recordings in vitro and in vivo

    Pierre Yger et al.
    A spike sorting toolbox to quickly and reliably access the activity of thousands of neurons recorded with dense extracellular probes.
    1. Neuroscience

    Dendritic Na+ spikes enable cortical input to drive action potential output from hippocampal CA2 pyramidal neurons

    Qian Sun et al.
    In the hippocampus, dendritic Na + spikes are required for signals from the entorhinal cortex to drive action potentials in CA2-but not CA1 or CA3-pyramidal neurons.
    1. Neuroscience

    SpikeInterface, a unified framework for spike sorting

    Alessio P Buccino et al.
    SpikeInterface is an open-source software framework designed to build full analysis pipelines for extracellular recordings in a seamless and reproducible way.
    1. Neuroscience

    Complex spike synchrony dependent modulation of rat deep cerebellar nuclear activity

    Tianyu Tang et al.
    The importance of synchronous Purkinje cell complex spikes for controlling cerebellar output was investigated by simultaneously recording from cerebellar nuclear cells and arrays of Purkinje cells that synapse onto them.
    1. Neuroscience

    Inferring synaptic inputs from spikes with a conductance-based neural encoding model

    Kenneth W Latimer et al.
    The conductance-based encoding model creates a new bridge between statistical models and biophysical models of neurons, and infers visually-evoked excitatory and inhibitory synaptic conductances from spike trains in macaque retina.
    1. Neuroscience

    Three rules govern thalamocortical connectivity of fast-spike inhibitory interneurons in the visual cortex

    Yulia Bereshpolova et al.
    In the visual system, three rules guide the thalamocortical connectivity of cortical fast-spike interneurons and are key to understand the potent and broadly tuned feed-forward inhibition that they generate.

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