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    1. Immunology and Inflammation

    SARS-CoV-2 uses CD4 to infect T helper lymphocytes

    Natalia S Brunetti, Gustavo G Davanzo ... Alessandro S Farias
    The infection of T helper lymphocytes by SARS-CoV-2, mediated via the CD4 molecule, alters cellular function and enhances expression of the anti-inflammatory cytokine IL-10, potentially impairing immune response in individuals with COVID-19.
    1. Microbiology and Infectious Disease

    Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape

    Fred D Mast, Peter C Fridy ... Michael P Rout
    A large repertoire of nanobodies that target discrete regions of SARS-CoV-2 spike shows effective neutralization against variants of concern with many pairwise combinations resistant to escape and demonstrating synergistic neutralization activities.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    The glycoprotein quality control factor Malectin promotes coronavirus replication and viral protein biogenesis

    Jonathan P Davies, Lars Plate
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology

    Cell membrane glycan contents are biochemical factors that constitute a kinetic barrier to viral particle uptake in a protein-nonspecific manner

    Yoshihisa Kaizuka, Rika Machida
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Solid
    1. Structural Biology and Molecular Biophysics

    Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization

    Siyang Sun, Ye Xiang ... Michael G Rossmann
    Electron cryo-microscopy has been used to determine the structure of Chikungunya virus-like particles and to provide new insights into their interactions with four different antibodies.
    1. Microbiology and Infectious Disease

    Lys417 acts as a molecular switch that regulates the conformation of SARS-CoV-2 spike protein

    Qibin Geng, Yushun Wan ... Fang Li
    Lys417 regulates the opening and closing of SARS-CoV-2 spike protein, allowing SARS-CoV-2 to maintain a delicate balance between infectiousness and evading host immune response.
    1. Microbiology and Infectious Disease

    Multimeric single-domain antibody complexes protect against bunyavirus infections

    Paul J Wichgers Schreur, Sandra van de Water ... Jeroen Kortekaas
    Llama-derived single-domain antibodies, formatted as bispecific antibodies with human Fc domains, reduce and prevent bunyavirus-induced morbidity and mortality in mice upon prophylactic and therapeutic administration.
    1. Biochemistry and Chemical Biology

    Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronaviruses

    Rui P Silva, Yimin Huang ... Jennifer A Maynard
    A new class of antibody binding a highly conserved epitope on the spike S2 domain of MERS-CoV, SARS-CoV, and SARS-CoV-2 viruses is described.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    The nanoscale organization of the Nipah virus fusion protein informs new membrane fusion mechanisms

    Qian Wang, Jinxin Liu ... Qian Liu
    Single-molecule localization imaging shows that the Nipah virus fusion protein forms nanoscale clusters on cell and viral membranes that favor membrane fusion activation.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike

    Marco A Díaz-Salinas, Qi Li ... James B Munro
    The function of the SARS-CoV-2 spike is controlled by allosterically modulating the dynamics of the receptor-binding domain.
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