1,390 results found
    1. Neuroscience

    Motor cortex can directly drive the globus pallidus neurons in a projection neuron type-dependent manner in the rat

    Fuyuki Karube et al.
    Globus pallidus neurons projecting to the striatum are preferentially activated by direct glutamatergic innervation from the motor cortex.
    1. Cell Biology
    2. Developmental Biology

    Single-cell proteomics reveals changes in expression during hair-cell development

    Ying Zhu et al.
    Protein mass spectrometry can be used to uncover developmental trajectories in small single cells of differentiating tissues.
    1. Human Biology and Medicine

    Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease

    Robert N Helsley et al.
    Loss of function of membrane-bound O-acyltransferase 7 (MBOAT7), but not transmembrane channel-like 4 (TMC4), promotes hepatic steatosis.
    1. Neuroscience

    Structured inhibitory activity dynamics in new virtual environments

    Moises Arriaga, Edward B Han
    Inhibitory interneuron activity is dynamically modulated in new environments while individual interneurons show consistent levels of activity modulation across multiple environments, suggesting functional specialization of inhibitory subnetworks.
    1. Cell Biology

    DNA damage checkpoint activation impairs chromatin homeostasis and promotes mitotic catastrophe during aging

    Matthew M Crane et al.
    Activation of a DNA-damage cell cycle checkpoint during aging causes genome instability and senescence in yeast mother cells.
    1. Epidemiology and Global Health

    The mother’s risk of premature death after child loss across two centuries

    Unnur A Valdimarsdóttir et al.
    A large-scale, sibling-based analysis of the Icelandic population spanning two centuries demonstrates an increase in maternal mortality rates after child loss on both sides of a major demographic transition.
    1. Chromosomes and Gene Expression

    CTCF confers local nucleosome resiliency after DNA replication and during mitosis

    Nick Owens et al.
    In contrast to other transcription factors, CTCF and Esrrb rapidly regain binding after replication and remain bound to their targets during mitosis, preserving local nucleosome organization throughout the cell cycle.
    1. Neuroscience

    Modular organization of cerebellar climbing fiber inputs during goal-directed behavior

    Shinichiro Tsutsumi et al.
    Motor and non-motor functions are represented in spatially segregated and temporally organized climbing fiber signals to distinct cerebellar zones during goal-directed behavior.
    1. Neuroscience

    Classical conditioning drives learned reward prediction signals in climbing fibers across the lateral cerebellum

    William Heffley, Court Hull
    Cerebellar climbing fibers can generate learned reward-predictive instructional signals, suggesting a role for cerebellar learning in the reinforcement of reward-driven behaviors.
    1. Neuroscience

    Cerebellar climbing fibers encode expected reward size

    Noga Larry et al.
    Electrophysiological recordings in monkeys reveal that cerebellar complex spikes encode future reward size when reward information is first made available, but not during reward delivery or smooth pursuit eye movement.

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