1,979 results found
    1. Developmental Biology
    2. Plant Biology

    Organ geometry channels reproductive cell fate in the Arabidopsis ovule primordium

    Elvira Hernandez-Lagana et al.
    In the Arabidopsis ovule primordium, germinal fate plasticity is coupled to the morphogenetic processes shaping the organ.
    1. Neuroscience

    Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociability

    Laifu Li et al.
    Inhibition of 5-HT neurons in the dorsal raphe nuclei or 5-HT terminals in the anterior cingulate cortex decreased consolation-like behaviors and reduced sociability.
    1. Computational and Systems Biology
    2. Neuroscience

    Low-dimensional learned feature spaces quantify individual and group differences in vocal repertoires

    Jack Goffinet et al.
    Modern machine learning methods offer new techniques for analyzing complex vocal behavior like ultrasonic mouse calls and birdsong.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    An evolutionary model identifies the main evolutionary biases for the evolution of genome-replication profiles

    Rossana Droghetti et al.
    Mathematical modeling and data analysis show that, over evolutionary times, the yeast temporal program of replication strives to avoid stalling events and minimize interference between neighbor origins.
    1. Cell Biology
    2. Neuroscience

    High-fidelity, efficient, and reversible labeling of endogenous proteins using CRISPR-based designer exon insertion

    Haining Zhong et al.
    A high-fidelity and efficient strategy to use CRISPR/Cas9 to reversibly insert large DNA fragments into somatic cells to label or modify endogenous proteins for research and, in the future, for gene therapy.
    1. Neuroscience

    Spatially displaced excitation contributes to the encoding of interrupted motion by a retinal direction-selective circuit

    Jennifer Ding et al.
    The direction-selective circuit in the retina adjusts the contributions of excitatory and inhibitory mechanisms under different stimulus conditions to generate context-dependent neural representations of visual features.
    1. Neuroscience

    Attenuated dopamine signaling after aversive learning is restored by ketamine to rescue escape actions

    Mingzheng Wu et al.
    Interconnected ventral tegmental area and medial prefrontal cortex circuits causally link dopamine dynamics, aversive learning, and the effects of a promising rapidly acting antidepressant ketamine.
    1. Neuroscience

    Working memory gates visual input to primate prefrontal neurons

    Behrad Noudoost et al.
    Visual input to prefrontal cortex preferentially targets neurons with both sensory and motor properties, and the synaptic efficacy of these inputs is facilitated by working memory.
    1. Ecology
    2. Plant Biology

    Genetic variation, environment and demography intersect to shape Arabidopsis defense metabolite variation across Europe

    Ella Katz et al.
    Measurements of specialized metabolites across a population of 800 natural Arabidopsis thaliana accessions revealed different pressures and evolutionary processes that shaped their variation and distribution across Europe.
    1. Developmental Biology
    2. Neuroscience

    Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors

    Gerrit Cornelis Beekhof et al.
    Different Purkinje cell subpopulations show distinct developmental profiles of physiological activity, climbing fiber inputs and axonal and dendritic morphology, matching different timelines of cerebellum-dependent behaviors.

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