2,011 results found
    1. Neuroscience

    Endocannabinoid dynamics gate spike-timing dependent depression and potentiation

    Yihui Cui et al.
    The molecular mechanisms beyond the bidirectionality (tTLP and tLTD) of endocanabinoid spike-timing dependent synaptic plasticity have been identified.
    1. Computational and Systems Biology
    2. Neuroscience

    Spike-timing-dependent ensemble encoding by non-classically responsive cortical neurons

    Michele N Insanally et al.
    During behavior, many neurons do not have classic trial-averaged responses to behaviorally relevant stimuli, but can still have activity and population dynamics related to stimulus and behavioral choice on single trials.
    1. Neuroscience

    Multiplexed coding by cerebellar Purkinje neurons

    Sungho Hong et al.
    Cerebellar Purkinje neurons use a multiplexed simple spike code combining synchrony/spike time and firing rate, with each component encoding distinct information about movements such as motion onset timing and kinematics.
    1. Neuroscience

    Dendritic small conductance calcium-activated potassium channels activated by action potentials suppress EPSPs and gate spike-timing dependent synaptic plasticity

    Scott L Jones et al.
    The activation of small-conductance calcium-activated potassium channels in spines by action potentials regulates the induction of spike-timing dependent synaptic plasticity during low-frequency single action potential–EPSP pairing.
    1. Neuroscience

    Control of voluntary and optogenetically perturbed locomotion by spike rate and timing of neurons of the mouse cerebellar nuclei

    Rashmi Sarnaik, Indira M Raman
    Stride-related modulated firing by neurons of the cerebellar nuclei is required for smooth execution of practiced locomotion and persists more easily with synchronous than asynchronous Purkinje-mediated inhibition.
    1. Neuroscience

    Coding strategies in the otolith system differ for translational head motion vs. static orientation relative to gravity

    Mohsen Jamali et al.
    Through different coding strategies, irregular and regular otolith afferents preferentially encode translational self-motion and changes in static head orientation relative to gravity.
    1. Neuroscience

    Recurrent network model for learning goal-directed sequences through reverse replay

    Tatsuya Haga, Tomoki Fukai
    The combination of short-term and long-term plasticity enables hippocampus to learn goal-directed paths through replay in a reversed order.
    1. Neuroscience
    2. Computational and Systems Biology

    Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning

    Rui Ponte Costa et al.
    Combined pre- and postsynaptically expressed long-term plasticity of neuronal connections improves sensory discrimination, and enables rapid relearning of previously encountered information.
    1. Neuroscience

    Retroactive modulation of spike timing-dependent plasticity by dopamine

    Zuzanna Brzosko et al.
    Dopamine, a reward signal in the brain, can retroactively convert hippocampal synaptic depression into potentiation, suggesting an elegant biological solution to the distal reward problem.
    1. Neuroscience

    Movement-related coupling of human subthalamic nucleus spikes to cortical gamma

    Petra Fischer et al.
    When coupling between STN spikes and cortical gamma oscillations was strong, subsequent movement was initiated earlier, independent of changes in mean firing rates, demonstrating the importance of relative spike timing.

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