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    1. Neuroscience

    Retroactive modulation of spike timing-dependent plasticity by dopamine

    Zuzanna Brzosko, Wolfram Schultz, Ole Paulsen
    Dopamine, a reward signal in the brain, can retroactively convert hippocampal synaptic depression into potentiation, suggesting an elegant biological solution to the distal reward problem.
    1. Neuroscience

    Movement-related coupling of human subthalamic nucleus spikes to cortical gamma

    Petra Fischer, Witold J Lipski ... R Mark Richardson
    When coupling between STN spikes and cortical gamma oscillations was strong, subsequent movement was initiated earlier, independent of changes in mean firing rates, demonstrating the importance of relative spike timing.
    1. Cell Biology

    SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation

    David W Sanders, Chanelle C Jumper ... Clifford P Brangwynne
    A high-throughput microscopy screen for drugs that modulate SARS-CoV-2 spike-mediated membrane fusion identifies an essential role for cholesterol in both virus entry and syncytia formation.
    1. Computational and Systems Biology
    2. Neuroscience

    Stochastic and deterministic dynamics of intrinsically irregular firing in cortical inhibitory interneurons

    Philipe RF Mendonça, Mariana Vargas-Caballero ... Hugh PC Robinson
    A-type potassium conductances influence the distinctive firing behaviour of irregular-spiking interneurons.
    1. Neuroscience

    Astrocytes mediate two forms of spike timing-dependent depression at entorhinal cortex-hippocampal synapses

    Irene Martínez-Gallego, Heriberto Coatl-Cuaya, Antonio Rodriguez-Moreno
    Two different forms of brain plasticity require astrocytes and show different action mechanisms at enthorrinal cortex hippocampal synapses.
    1. Neuroscience
    2. Computational and Systems Biology

    Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning

    Rui Ponte Costa, Robert C Froemke ... Mark CW van Rossum
    Combined pre- and postsynaptically expressed long-term plasticity of neuronal connections improves sensory discrimination, and enables rapid relearning of previously encountered information.
    1. Neuroscience

    Sucrose intensity coding and decision-making in rat gustatory cortices

    Esmeralda Fonseca, Victor de Lafuente ... Ranier Gutierrez
    The neural representation of perceived sucrose intensity was contained in the firing rate and spike-timing of a 'small' population of neurons distributed across the Insula and Orbitofrontal taste cortices.
    1. Neuroscience

    Recurrent network model for learning goal-directed sequences through reverse replay

    Tatsuya Haga, Tomoki Fukai
    The combination of short-term and long-term plasticity enables hippocampus to learn goal-directed paths through replay in a reversed order.
    1. Neuroscience

    Coding strategies in the otolith system differ for translational head motion vs. static orientation relative to gravity

    Mohsen Jamali, Jerome Carriot ... Kathleen E Cullen
    Through different coding strategies, irregular and regular otolith afferents preferentially encode translational self-motion and changes in static head orientation relative to gravity.
    1. Neuroscience

    Firing rate-dependent phase responses of Purkinje cells support transient oscillations

    Yunliang Zang, Sungho Hong, Erik De Schutter
    Computational and theoretical models show that rate adaptation of phase responses can regulate Purkinje cell outputs by forming transient oscillations in fast-spiking neurons.