718 results found
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion

    Jiajie Diao, Patricia Grob ... Axel T Brunger
    A combination of advanced optical imaging and cryogenic electron microscopy has been used to explore membrane fusion in a synthetic system and provide new insights into neurotransmitter release.
    1. Neuroscience

    Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo

    Verena Pawlak, David S Greenberg ... Jason ND Kerr
    Changing the order in which presynaptic and postsynaptic cells are repeatedly activated can change what a mammalian visual cortex neuron communicates to downstream neurons.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates

    Tijana Ivanovic, Jason L Choi ... Stephen C Harrison
    Long-lived intermediate states formed by glycoprotein catalysts are an essential part of the process used by influenza virus particles to infect cells.
    1. Chromosomes and Gene Expression

    DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

    Benjamin JM Taylor, Serena Nik-Zainal ... Michael S Neuberger
    Enzymes that remove amine groups from cytosine bases in DNA are likely involved in generating the clusters of mutations (kataegis) seen in breast cancer.
    1. Neuroscience

    Tapered whiskers are required for active tactile sensation

    Samuel Andrew Hires, Lorenz Pammer ... David Golomb
    The tapered, conical shape of rodent whiskers is essential for sensor mobility in constrained spaces and feature extraction from textured surfaces.
    1. Neuroscience

    Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar

    Ana I Domingos, Aylesse Sordillo ... Jeffrey M Friedman
    Natural sugars are preferred over artificial sweeteners because of their nutritional content, which is sensed by MCH neurons in the lateral hypothalamus.
    1. Neuroscience

    CA1 cell activity sequences emerge after reorganization of network correlation structure during associative learning

    Mehrab N Modi, Ashesh K Dhawale, Upinder S Bhalla
    As mice learn to associate events separated in time, neurons within the CA1 region of the hippocampus progressively reorganize their firing patterns, leading to a relay of cellular activity that bridges the two events.
    1. Neuroscience

    Regulation of branching dynamics by axon-intrinsic asymmetries in Tyrosine Kinase Receptor signaling

    Marlen Zschätzsch, Carlos Oliva ... Bassem A Hassan
    Asymmetric localization of the receptor EGFR within branches of axons is required to establish the precise wiring of neuronal networks within the Drosophila brain.
    1. Neuroscience

    Gating of neural error signals during motor learning

    Rhea R Kimpo, Jacob M Rinaldi ... Jennifer L Raymond
    Electrode recordings and optogenetics reveal that the cerebellum can modulate its response to error signals from the brainstem during motor learning.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Expression site attenuation mechanistically links antigenic variation and development in Trypanosoma brucei

    Christopher Batram, Nicola G Jones ... Markus Engstler
    The VSG gene controls its monoallelic expression, and expression site activity determines developmental progression.

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