In addition to its classic role in synaptic function and plasticity, macroautophagy regulates neuronal intrinsic excitability via degradation of acetylated Kir2 channels to control neurotransmission.
Cholecystokinin-positive neural projection from entorhinal cortex to lateral amygdala modulates the long-term potentiation of auditory-evoked potential in lateral amygdala and underlies the formation of trace fear memory.
Central vestibular regions in the brainstem and cerebellum perform dynamic Bayesian inference to combine motor commands and sensory signals into an optimal estimate of self-motion.
Type IV collagen plays a dual role in both structurally fastening tissues and signaling through the discoidin domain receptor 2 to synchronize an integrin adhesion that stabilizes tissue linkage.
Local disinhibition provides a biologically plausible mechanism for flexible top-down control of network states that integrates normalized value coding, winner-take-all choice, and persistent activity in a single circuit of decision-making.
Patrícia A Correia, Eran Lottem ... Zachary F Mainen
Phasic activation of dorsal raphe serotonin neurons transiently inhibits locomotion without influencing anxiety or producing reinforcement, but when repeated over many days a long-term facilitation of locomotion is produced.
The GABA input switching from excitatory to inhibitory during maturation of adult-born dentate granule cells is crucial for their integration into the preexisting circuit.
Colin Echeverría Aitken, Petra Beznosková ... Jon R Lorsch
Eukaryotic translation initiation factor 3 (eIF3) is required to stabilize the binding of mRNA at the exit channel of the small ribosomal subunit and acts at the entry channel to accelerate mRNA recruitment to the translation preinitiation complex.
