Verena Pawlak, David S Greenberg ... Jason ND Kerr
Changing the order in which presynaptic and postsynaptic cells are repeatedly activated can change what a mammalian visual cortex neuron communicates to downstream neurons.
Electron cryo-microscopy has been used to determine the structure of Chikungunya virus-like particles and to provide new insights into their interactions with four different antibodies.
Benjamin JM Taylor, Serena Nik-Zainal ... Michael S Neuberger
Enzymes that remove amine groups from cytosine bases in DNA are likely involved in generating the clusters of mutations (kataegis) seen in breast cancer.
Sean Michael Boyle, Shane McInally, Anandasankar Ray
A computational method that can screen thousands of chemicals and predict which odorants will interact with specific odorant receptors in flies may ultimately aid the development of more effective insect repellents.
Jessica L Metcalf, Laura Wegener Parfrey ... Rob Knight
High-throughput sequencing has been used to analyze the microbiome of mouse corpses over a period of 48 days, and to provide an accurate estimate of the time since death.
The simultaneous monitoring of transcription, translational control, protein production and proteolysis in the same system can improve our understanding of how cancer cells respond to chemotherapy.
Computer simulations of interaural time difference decoders show that heterogeneous tuning of binaural neurons leads to accurate sound localization in natural environments.
Anwesha Nag, Virginia Savova ... Alexander A Gimelbrant
Active and repressive chromatin marks, asymmetrically distributed between alleles, distinguish gene bodies subject to epigenetically controlled monoallelic expression on autosomes in human cells.