1,390 results found
    1. Neuroscience

    Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo

    Verena Pawlak, David S Greenberg ... Jason ND Kerr
    Changing the order in which presynaptic and postsynaptic cells are repeatedly activated can change what a mammalian visual cortex neuron communicates to downstream neurons.
    1. Structural Biology and Molecular Biophysics

    Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization

    Siyang Sun, Ye Xiang ... Michael G Rossmann
    Electron cryo-microscopy has been used to determine the structure of Chikungunya virus-like particles and to provide new insights into their interactions with four different antibodies.
    1. Chromosomes and Gene Expression

    DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

    Benjamin JM Taylor, Serena Nik-Zainal ... Michael S Neuberger
    Enzymes that remove amine groups from cytosine bases in DNA are likely involved in generating the clusters of mutations (kataegis) seen in breast cancer.
    1. Neuroscience

    Controlling gain one photon at a time

    Gregory W Schwartz, Fred Rieke
    Single absorbed photons trigger adaptational mechanisms that help the retina maintain sensitivity across a wide range of background illumination.
    1. Neuroscience

    Expanding the olfactory code by in silico decoding of odor-receptor chemical space

    Sean Michael Boyle, Shane McInally, Anandasankar Ray
    A computational method that can screen thousands of chemicals and predict which odorants will interact with specific odorant receptors in flies may ultimately aid the development of more effective insect repellents.
    1. Ecology
    2. Microbiology and Infectious Disease

    A microbial clock provides an accurate estimate of the postmortem interval in a mouse model system

    Jessica L Metcalf, Laura Wegener Parfrey ... Rob Knight
    High-throughput sequencing has been used to analyze the microbiome of mouse corpses over a period of 48 days, and to provide an accurate estimate of the time since death.
    1. Biochemistry and Chemical Biology

    Global cellular response to chemotherapy-induced apoptosis

    Arun P Wiita, Etay Ziv ... James A Wells
    The simultaneous monitoring of transcription, translational control, protein production and proteolysis in the same system can improve our understanding of how cancer cells respond to chemotherapy.
    1. Neuroscience

    Tapered whiskers are required for active tactile sensation

    Samuel Andrew Hires, Lorenz Pammer ... David Golomb
    The tapered, conical shape of rodent whiskers is essential for sensor mobility in constrained spaces and feature extraction from textured surfaces.
    1. Neuroscience

    Decoding neural responses to temporal cues for sound localization

    Dan FM Goodman, Victor Benichoux, Romain Brette
    Computer simulations of interaural time difference decoders show that heterogeneous tuning of binaural neurons leads to accurate sound localization in natural environments.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Chromatin signature of widespread monoallelic expression

    Anwesha Nag, Virginia Savova ... Alexander A Gimelbrant
    Active and repressive chromatin marks, asymmetrically distributed between alleles, distinguish gene bodies subject to epigenetically controlled monoallelic expression on autosomes in human cells.

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